Medical University Of Vienna

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This study tests a simple injection of mashed parathyroid tissue into the forearm during thyroid surgery. The goal is to prevent permanent low calcium levels that require lifelong medication. About 100 adults having thyroid surgery will receive this injection, and researchers wil…

This study tests a toric add-on lens placed in the eye to correct high astigmatism in people who have already had a corneal transplant and cataract surgery. The goal is to reduce blurry vision from astigmatism without removing the original lens. About 40 participants will be foll…

This study tests using a drug-coated balloon instead of a permanent stent to open blocked arteries during a heart attack. The balloon delivers medication to prevent re-blockage without leaving a metal implant. Researchers will track 300 participants to see if this approach is saf…

This study compares two different stent systems used to repair a weakened area in the main artery (aortic aneurysm). About 126 adults will be randomly assigned to receive either the BeFlared or the VBX stent during a minimally invasive procedure. The goal is to see which device t…

This study tests a combination of drugs given in low, frequent doses to slow or stop the growth of recurrent brain tumors in children. The goal is to extend survival while maintaining quality of life. About 232 children with medulloblastoma, ependymoma, ATRT, or other rare CNS tu…

This early-phase study tests a new drug called BT200 in 4-6 adults with type 2B von Willebrand disease who have low platelets and a history of bleeding. The drug is designed to raise von Willebrand factor and platelet levels, which may lower the risk of bleeding. Participants rec…

This study tests a drug called datopotamab-deruxtecan (Dato-DXd) in 20 people with triple-negative breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors. Participants must have newly diagnosed or worsening brain metastases. The study i…

This study looks at how the bones and soft tissues of the face change when the upper jaw is widened using a custom-made expansion device anchored to temporary bone screws. 38 people with a narrow upper jaw and crossbite will receive orthodontic treatment and have their progress t…

This study checks how well standard devices measure blood flow in patients on ECMO, a machine that adds oxygen to blood outside the body. About 30 adults on ECMO will have their blood flow measured using different methods, including ultrasound and a leg-raising test. The goal is …

This study checks how well standard devices measure blood flow in 30 adults on ECMO, a machine that pumps and oxygenates blood outside the body. The goal is to see if these monitors give accurate readings during this special situation. Results could help doctors better manage flu…

This study tests whether a small device that gently stimulates a nerve in the ear can help people with long-term back pain. 48 adults will either get the ear stimulation plus standard rehab, or rehab alone, for 3 weeks. The goal is to see if the device improves daily function and…

This study explores whether psilocybin, the active ingredient in magic mushrooms, can help people with depression who have lost the ability to feel pleasure (anhedonia). Researchers will give 85 participants two doses of psilocybin, sometimes blocking its psychedelic effects with…

This study tests whether a device that sends gentle sound pulses to the brain can reduce fatigue, brain fog, and mood problems in people with long COVID. 102 adults who have had COVID-19 at least 12 months ago will receive either real or fake (sham) treatment over five sessions. …

This study compares standard monofocal intraocular lenses (IOLs) with enhanced monofocal IOLs in 461 people having cataract surgery. The goal is to see if the enhanced lenses improve vision at intermediate distances, like reading a computer screen, while maintaining good distance…

This study tests whether letting patients choose and listen to their own music during anesthesia induction and emergence can lower anxiety and improve comfort. One hundred adults having eye surgery will be randomly assigned to either hear their chosen music or receive standard ca…

This study tests whether taking a daily lactobacillus probiotic can reduce symptoms of overactive bladder in women. One hundred women with the condition will take either the probiotic or a placebo for six months. Researchers will track symptom changes and check the bacteria in th…

This study looks at whether using a video laryngoscope (a camera-equipped scope) helps doctors place a breathing tube through the nose more successfully on the first try compared to a standard direct laryngoscope in infants under 1 year with congenital heart disease. About 180 in…

This pilot study is testing whether low-dose radiation can safely reduce pain from arthritis of the temporomandibular joint (jaw joint). Ten adults over 50 with diagnosed TMJ arthritis will receive six small doses of radiation over two weeks. Researchers will track pain levels an…

This study tests whether a 6-week outpatient pulmonary rehabilitation program helps people with post-PE syndrome (lingering symptoms after a pulmonary embolism) walk farther and breathe better. About 48 adults who had a pulmonary embolism 12 to 36 weeks earlier will be randomly a…

This study looks at whether a new cyclosporin eye drop (Vevizye®) can reduce inflammation and dryness in people with moderate to severe dry eye disease who still have symptoms after using artificial tears. About 25 adults with chronic dry eye and visible eye redness will use the …

This observational study will follow 1300 critically ill adults in intensive care to see if a blood test called anti-factor Xa activity can predict dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, quality of life, and…

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…

This study looks at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a tool that uses pump signals to predict whether a patient's own heart will recover. The goal is to improve decision-making and reduce complications li…

This study is a registry that will follow 500 people with primary biliary cholangitis (PBC) in Austria. Researchers will collect medical data and optional blood or liver samples to learn how the disease progresses and what complications arise. No new treatment is being tested; th…

This study looks at whether performing CPR affects how well medical professionals remember a patient's history. Thirty-eight healthy doctors, nurses, and paramedics will either listen to a patient story while doing CPR or just listen without any task. After each scenario, they an…

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study tests whether using a tablet for live video interpreting helps emergency doctors communicate with patients who don't speak the same language. Fifty awake adult patients with language barriers will be included. The researchers will measure how well the technology works,…

This study looks at how certain diabetes medications (semaglutide, liraglutide, and tirzepatide) affect blood flow and oxygen use in the eyes of people with diabetes. Researchers will use special cameras to measure eye blood vessels and oxygen levels in 20 adults before and after…

This study is testing whether a personalized approach to choosing cancer drugs can help people with glioblastoma, an aggressive brain tumor. Researchers will take tumor tissue from each patient, grow the cells in a lab, and test many drugs to find which ones work best. Then, pati…

This study watches how different hospitals help ICU patients start moving early. Researchers will track 6,000 adults to see which rehab methods lead to better strength and quality of life. No new treatments are given—only routine care is recorded.

This study is looking at whether certain substances in the blood can help predict postoperative delirium—a state of confusion that can occur after surgery in older adults. Researchers will measure specific biomarkers before and after surgery in 1,170 patients aged 65 and older un…

This study follows 5,000 patients who spent more than 72 hours in the ICU to understand long-term cognitive, physical, and emotional problems known as Post-Intensive Care Syndrome (PICS). Researchers will collect data during the hospital stay and for up to five years after discha…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in 50 healthy adults aged 18 to 80 using non-invasive eye scans. The goal is to understand normal aging, which may help future studies on eye diseases.

This study looks at how gender-affirming hormone therapy with testosterone or estrogen changes heart function, fat in the liver and heart, and insulin sensitivity. Researchers will follow 40 transgender adults (20 male-to-female, 20 female-to-male) for 6 months using MRI scans an…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This study follows 50 transgender men and women who have been on gender-affirming hormone therapy for 2 years. Researchers will use MRI scans, blood tests, and questionnaires to track changes in heart function, fat in the heart, liver, and pancreas, insulin system, and mental hea…

This study is looking for ways to predict which patients with severe depression will respond well to electroconvulsive therapy (ECT). Researchers will use brain scans, blood tests, and spinal fluid samples from 30 patients before and after ECT. The goal is to find biological mark…

This study looks at 20 people with hypertrophic obstructive cardiomyopathy who are already on optimal medical therapy. Researchers want to see if changes in heart blood flow over one year are linked to changes in how far they can walk in six minutes. Participants will have two he…