Hormone Therapy's hidden heart effects under the microscope
NCT ID NCT06245681
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how gender-affirming hormone therapy with testosterone or estrogen changes heart function, fat in the liver and heart, and insulin sensitivity. Researchers will follow 40 transgender adults (20 male-to-female, 20 female-to-male) for 6 months using MRI scans and glucose tests. The goal is to better understand the cardiovascular risks and benefits of these hormones.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gender-affirming hormone therapy (testosterone or estrogen)
What this could lead to
If successful, this study could clarify how sex hormones influence heart health and fat distribution, potentially guiding safer hormone therapy for transgender individuals.
What could go wrong
This is a small pilot study with only 40 participants, so results may not apply to everyone. It observes changes but does not test a new treatment, so no direct health benefits are expected.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Chiari Stoffwechselambulanz, Medical University of Vienna
RECRUITINGVienna, State of Vienna, 1090, Austria
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact