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Promising combo therapy offers hope for kids with hard-to-treat brain cancers

NCT ID NCT01356290

Recruiting now Disease control Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of drugs given in low, frequent doses to slow or stop the growth of recurrent brain tumors in children. The goal is to extend survival while maintaining quality of life. About 232 children with medulloblastoma, ependymoma, ATRT, or other rare CNS tumors will receive this anti-angiogenesis therapy. The study is currently recruiting.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor central nervous system neoplasm ependymoma medulloblastoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRT RECURRENT EPENDYMOMA RECURRENT MEDULLOBLASTOMA RECURRENT RARE CNS TUMOR RECURRENT

Contacts and locations

Locations

  • Akademiska sjukhuset

    RECRUITING

    Uppsala, 751 85, Sweden

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    TERMINATED

    Chicago, Illinois, 60611-2605, United States

  • Centre Léon Bérard

    RECRUITING

    Lyon, 69373, France

  • Centre Oscar Lambret

    TERMINATED

    Lille, 59037, France

  • Dana-Farber Cancer Institute and Boston Children's Hospital

    TERMINATED

    Boston, Massachusetts, 02215, United States

  • Dell Children's Medical Group SFC-HEM/ONC

    RECRUITING

    Austin, Texas, 78723, United States

  • Helen DeVos Children's Hospital

    RECRUITING

    Grand Rapids, Michigan, 48503, United States

  • Hospital Infantil Universitario Nino Jesus

    RECRUITING

    Madrid, 28009, Spain

  • Karolinska University Hospital

    RECRUITING

    Stockholm, SE-171 76, Sweden

  • Kepler Universitätsklinikum Med Campus IV

    RECRUITING

    Linz, 4020, Austria

  • Medical University of Graz

    RECRUITING

    Graz, 8036, Austria

  • Medical University of Innsbruck

    RECRUITING

    Innsbruck, 6020, Austria

  • Medical University of Vienna

    RECRUITING

    Vienna, 1090, Austria

  • Motol University Hospital Prague

    RECRUITING

    Prague, 15006, Czechia

  • Norrlands Universitetssjukhus

    RECRUITING

    Umeå, 901 85, Sweden

  • Onkologisk-hematologisk seksjon Barneklinikken Haukeland universitetssjukehus

    RECRUITING

    Bergen, 5021, Norway

  • Sahlgrenska Universitetssjukhuset

    RECRUITING

    Gothenburg, 416 85, Sweden

  • Salzburger Universitätsklinikum

    RECRUITING

    Salzburg, 5020, Austria

  • Skånes universitetssjukhus

    RECRUITING

    Lund, 221 85, Sweden

  • Universitetssjukhuset Linköping

    RECRUITING

    Linköping, 581 85, Sweden

  • University Hospital Brno

    RECRUITING

    Brno, 61300, Czechia

  • University hospital Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

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