Hoffmann-la Roche

This study looked at the long-term safety of faricimab, a medicine injected into the eye, for people with diabetic macular edema (swelling in the back of the eye caused by diabetes). About 1,500 patients who had already completed earlier studies received faricimab injections on a…

This study tested a new way to give two cancer drugs (tiragolumab and atezolizumab) together as a single injection. It included 64 people with advanced solid tumors that had spread or come back. The main goal was to check safety and how the drugs move through the body, not to cur…

This study tested whether adding tiragolumab to atezolizumab (both immunotherapy drugs) helps prevent non-small cell lung cancer from coming back after complete surgical removal and standard chemotherapy. 56 adults with stage IIB-IIIB PD-L1 positive tumors participated. The main …

This study tested two doses of an experimental drug called RO7247669 in 93 people with advanced melanoma that could not be removed by surgery or had spread. The goal was to see if the drug could control the cancer and help people live longer without it getting worse. Researchers …

This study tested whether using a patient's genetic profile to choose cancer treatment works better than standard chemotherapy for people with cancer of unknown primary site (CUP). About 529 adults whose cancer was controlled after initial chemo were randomly assigned to either p…

This study tested different combinations of immunotherapy drugs given before surgery to people with liver cancer that could be removed. The goal was to see if these treatments could shrink the tumor or eliminate it entirely before the operation. 62 participants took part, and the…

This study looked at the long-term safety of faricimab, an injected eye medication, in over 1,000 people with wet age-related macular degeneration (AMD). Participants had already completed earlier studies and continued receiving faricimab at personalized intervals. The main goal …

This study tested a new drug called PF-06480605 in 246 adults with moderate to severe ulcerative colitis. For the first 12 weeks, some participants received the drug and others received a placebo. After that, everyone received the active drug for 40 weeks. The goal was to see if …

This study tested an experimental drug called vamikibart, given as an eye injection, for people with uveitic macular edema — swelling in the back of the eye caused by inflammation. 256 adults with this condition took part. The main goal was to see if the drug improved vision by a…

This study tested whether a combination of venetoclax (a pill) and obinutuzumab (an infusion) works better than standard chemotherapy for people with untreated chronic lymphocytic leukemia (CLL) who are otherwise healthy. 166 fit adults took part. The goal was to see if the new c…

This study looked at how well and how safely the drug ocrelizumab works over a longer period for people with multiple sclerosis (MS). It included over 1,000 participants who had already been in earlier Roche studies of ocrelizumab. The goal was to track disability changes, relaps…

This study tested a drug called emicizumab in 85 people with hemophilia A, a condition where blood doesn't clot properly. Participants received either weekly or monthly shots of emicizumab or no preventive treatment. The goal was to see if the drug could reduce the number of blee…

This study tested an experimental drug called vamikibart, given as an eye injection, for people with uveitic macular edema — swelling in the back of the eye caused by inflammation. The trial involved 245 adults and compared the drug to a sham (fake) injection. The main goal was t…

This early-stage study tested a new drug called forimtamig in 225 people with multiple myeloma that had returned or stopped responding to standard treatments. The main goal was to check the drug's safety and find the right dose. Participants received the drug alone, and researche…

This study tested a new combination of two drugs (obinutuzumab and venetoclax) against a standard combination (obinutuzumab and chlorambucil) in 445 people with untreated chronic lymphocytic leukemia (CLL) who also had other medical conditions. The main goal was to see which comb…

This study tested a drug called risdiplam in 174 adults and children with spinal muscular atrophy (SMA), a genetic disease that weakens muscles. The goal was to see if the drug is safe and how the body processes it. Participants had previously received other SMA treatments. The s…

This study tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. It involved 174 adults with moderate-to-severe non-proliferative diabetic retinopathy. The goal was to see if the implant could improve…

This study tested a combination of two drugs (atezolizumab and cabozantinib) against a standard chemotherapy (docetaxel) in 366 people with advanced non-small cell lung cancer that had worsened after prior treatments. The goal was to see if the combination helped people live long…

This study tested whether a shot (subcutaneous) form of the immunotherapy drug atezolizumab works as well as the standard IV version for people with advanced non-small cell lung cancer. About 438 patients who had already tried platinum-based chemotherapy took part. The goal was t…

This study looked at the long-term safety of the drug tocilizumab (RoActemra/Actemra) in children with a type of juvenile arthritis. Seven children from France who finished a previous study received the drug every 4 weeks for up to 2 years. The main goal was to track any side eff…

This study tested new combinations of drugs in 281 adults with chronic hepatitis B who had stable liver function and were already on standard antiviral therapy. The goal was to see if these combinations could clear the hepatitis B surface antigen (a key marker of infection) and k…

This study tested whether a combination of two immunotherapy drugs (atezolizumab and tiragolumab) works better than the current standard drug (durvalumab) for people with stage III lung cancer that cannot be removed by surgery. Participants had already received chemotherapy and r…

This study tested several drug combinations in 12 people with advanced head and neck cancer that had not been treated yet. The goal was to see if the drugs could make tumors disappear or shrink before surgery. The study is now complete, and the results help guide future treatment…

This study tested a medicine called emicizumab in 73 people with mild or moderate hemophilia A (a bleeding disorder) who do not have inhibitors. The goal was to see if it safely reduces the number of bleeding episodes. Participants received regular injections, and researchers tra…

This study tested whether adding tiragolumab to atezolizumab helps people with advanced non-small cell lung cancer that hasn't been treated yet. About 620 participants received either the combination or a placebo plus atezolizumab. The goal was to see if the new combo slows cance…

This study tested whether adding the drug atezolizumab to standard chemotherapy before surgery helps people with early-stage lung cancer. About 450 adults with stage II or III non-small cell lung cancer took part. The goal was to see if the combination delays cancer return and im…

This study tested a drug called TRO19622 in 22 adults with NASH, a liver condition linked to fat buildup. Participants took either the drug or a placebo daily for one month. The goal was to see if the drug safely lowered liver enzyme levels, which are markers of liver injury. Res…

This study tested an investigational drug called RO7200220 (vamikibart) given as an eye injection for people with diabetic macular edema, a condition where diabetes causes swelling in the center of the retina and blurs vision. The trial involved 394 participants and compared the …

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps people with advanced triple-negative breast cancer that came back within a year of prior treatment. About 595 participants received either the drug combo or a placebo plus chemo. T…

This study tested a drug called crovalimab in 95 people with sickle cell disease to see if it could prevent painful vaso-occlusive episodes (VOEs), also known as sickle cell crises. Participants received either crovalimab or a placebo alongside their usual treatments. The goal wa…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This study looked at 70 pregnant women with multiple sclerosis or clinically isolated syndrome who received ocrelizumab before or during early pregnancy. Researchers measured B cell levels in their infants to see how much of the drug passed through the placenta. The goal was to u…

This study measured the thickness of the conjunctiva and Tenon's capsule (layers on the front of the eye) in 736 people with wet age-related macular degeneration or diabetic macular edema, as well as in healthy adults of similar age. Researchers used a special eye scanner (SD-OCT…

This study looked at whether using a blood test (liquid biopsy) early in the diagnosis process could help people with advanced lung or gastrointestinal cancer get diagnosed and start treatment sooner. 463 adults with suspected advanced cancer that had not yet been confirmed took …