Lung cancer patients may soon get immunotherapy as a quick shot instead of a long IV drip

NCT ID NCT03735121

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a subcutaneous (under-the-skin) injection of the immunotherapy drug atezolizumab works as well as the standard intravenous (IV) infusion in people with advanced non-small cell lung cancer who had already tried platinum-based chemotherapy. The trial enrolled 438 participants and had two parts: first to find the right dose for the shot, then to confirm that the shot delivers similar drug levels in the blood. If successful, this could make treatment much more convenient.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atezolizumab (Tecentriq) and rHuPH20 (ENHANZE)
What this could lead to: If successful, this could offer a more convenient, faster way to receive atezolizumab as a shot under the skin instead of a lengthy IV infusion.
What could go wrong: This is a Phase 3 trial, but it primarily checks whether the subcutaneous version reaches similar drug levels in the blood. It may not show better cancer control or survival, and there could be injection-site reactions.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

APHM

Marseille, 13385, France
Asan Medical Center

Seoul, 05505, South Korea
Asst Papa Giovanni XXIII

Bergamo, Lombardy, 24128, Italy
Auckland City Hospital, Cancer and Blood Research

Auckland, 1023, New Zealand
Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
Bradford Hill Centro de Investigaciones Clinicas

Recoleta, 8420383, Chile
Centro Medico Monte Carmelo

Arequipa, 04001, Peru
Centro Oncologico Riojano Integral (CORI)

La Rioja, F5300COE, Argentina
Centrum Terapii Wspolczesnej

Lodz, 93-319, Poland
Chelyabinsk Regional Clinical Oncology Dispensary

Chelyabinsk, Moscow Oblast, 454087, Russia
Christchurch Clinical Studies Trust Ltd

Christchurch, New Zealand
Chulalongkorn Hospital

Bangkok, 10330, Thailand
Clinica CIMCA

San José, 10103, Costa Rica
Clinica Internacional, Sede San Borja

Lima, Lima 41, Peru
Clínica San Gabriel

Lima, 15088, Peru
Communal Non profit Enterprise Regional Center of Oncology

Kharkiv, Kharkiv Governorate, 61070, Ukraine
Consultorio Dr. Miguel Angel Escudero

Salta, 4400, Argentina
Cuidados oncologicos

Querétaro City, Querétaro, 76000, Mexico
Ege Uni Medical Faculty Hospital

Izmir, 35100, Turkey (Türkiye)
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF

Moscow, Moscow Oblast, 115478, Russia
Faculty of Med. Siriraj Hosp.

Bangkok, 10700, Thailand
Filial #1 Regional Oncology Dispensary of Nizhniy Novgorod

Nizhny Novgorod, Niznij Novgorod, 603081, Russia
Fundación CENIT para la Investigación en Neurociencias

Buenos Aires, C1125ABD, Argentina
General Hospital "G.Papanikolaou"

Asvestochóri, 570 10, Greece
Groote Schuur Hospital ( Uni of Capetown )

Cape Town, 7506, South Africa
Grupo Angeles

Guatemala City, 01015, Guatemala
Health Pharma Professional Research

Mexico City, Mexico CITY (federal District), 03100, Mexico
Henan Cancer Hospital

Zhengzhou, 450008, China
Hospital El Pilar

Guatemala City, 01015, Guatemala
Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
ICIMED Instituto de Investigación en Ciencias Médicas

San José, 10108, Costa Rica
INCA 1- Instituto Nacional de Câncer X

Rio de Janeiro, 20231-050, Brazil
INTEGRA Cancer Institute

Guatemala City, 01010, Guatemala
IRCCS Istituto Clinico Humanitas

Rozzano, Lombardy, 20089, Italy
Ico Rene Gauducheau

Saint-Herblain, 44805, France
Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo, 01246-000, Brazil
Ivano-Frankivsk Regional Oncology Center

Ivano-Frankivsk, 76018, Ukraine
James Lind Centro de Investigación Del Cáncer

Temuco, 4800827, Chile
Jilin Cancer Hospital

Changchun, 132013, China
Jinan Central Hospital

Jinan, 250013, China
MEDSI Clinical Hospital on Pyatnitsky Highway

Moscow, Moscow Oblast, 143422, Russia
Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, 50200, Thailand
Matrai Gyogyintezet

Mátraháza, 3233, Hungary
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy

Otwock, 05-400, Poland
Medipol University Medical Faculty

Istanbul, 34214, Turkey (Türkiye)
Mordovia State University

Saransk, Respublika Mordoviya, 430032, Russia
Multidisciplinary clinic Reaviz

Samara, 443011, Russia
Municipal Institution City Clinical Hospital #4 of Dnipro City Council

Dnipropetrovsk, Katerynoslav Governorate, 49102, Ukraine
Murmansk Regional Clinical Hospital named after P.A. Bayandin

Murmansk, 183047, Russia
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie

Warsaw, 02-781, Poland
Oncocentro Apys

Viña del Mar, 2520598, Chile
Oncomedica

Guatemala City, 01010, Guatemala
Oncosalud Sac

Lima, 41, Peru
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Prapokklao Hospital

Chanthaburi, 22000, Thailand
Prince of Songkla University

Hat Yai, 90110, Thailand
RCI Sumy Regional Clinical Oncological Dispensary

Sumy, 40005, Ukraine
Rajavithi Hospital

Bangkok, 10400, Thailand
Református Pulmonológiai Centrum

Törökbálint, 2045, Hungary
Regionalny Szpital Specjalistyczny im. W. Bieganskiego

Grudzi?dz, 86-300, Poland
Riga East Clinical University Hospital Latvian Oncology Centre

Riga, LV-1079, Latvia
SBIH Kaluga Region Clinical Oncology Dispensary

Kaluga, 248007, Russia
Samsung Medical Centre

Seoul, 135-170, South Korea
Sandton Oncology Medical Group

Sandton, 2196, South Africa
Sir Run Run Shaw Hospital Zhejiang University

Hangzhou, 310016, China
Sotiria Hospital

Athens, 104 31, Greece
Tauranga Hospital, Clinical Trials Unit

Tauranga, 3112, New Zealand
Udonthani Cancer Hospital, Udonthani

Muang,Udonthani, 41330, Thailand
Vajira Hospital

Bangkok, 10300, Thailand
Waikato Hospital - Cancer and Blood Research Trials Unit

Hamilton, 3204, New Zealand
West China Hospital - Sichuan University

Chengdu, 610047, China
Wilgers Oncology Centre

Pretoria, 0001, South Africa

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