Guy's And St Thomas' Nhs Foundation Trust

This study looks at 70 people with heart failure, atrial fibrillation (an irregular heartbeat), and a special pacemaker (CRT). The pacemaker is not working as well as it should. Participants will be randomly assigned to one of two procedures: ablation of the area causing the irre…

This study tests a special light treatment (photodynamic therapy) given inside the nose just before surgery to see if it can prevent infections. About 80 adults having nose surgery will either get the light treatment or a placebo swab. The main goal is to see if fewer people need…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be an effective alternative to antibiotic tablets for women with bacterial vaginosis or thrush. About 114 women will be randomly assigned to use either lactoferrin vaginal pessaries or standard oral an…

This study tests whether a 3-month at-home listening training program (BEARS) can help children aged 8 to 16 with two cochlear implants understand speech in noisy environments. Participants will be randomly assigned to receive the training plus usual care or usual care alone. The…

This study tests a new way of using a breathing machine (ventilator) for people with slowly worsening muscle diseases like muscular dystrophy. The goal is to see if adjusting the machine to deliver a set amount of air each breath can improve overnight oxygen and carbon dioxide le…

This study tests a new NHS program to help adults with type 1 diabetes manage diabetes distress—feelings like worry, frustration, or burnout. About 110 participants will try an online group program or enhanced usual care. The goal is to see if this approach is practical and helpf…

This observational study aims to see if people with REM sleep behavior disorder (RBD) have a higher rate of concussions or contact sports history compared to those without RBD. About 140 participants, aged 50 and older, will answer questions about past head injuries and sports. T…

This study looks at 20 adults in the ICU with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see if using inhaled sedation (like the gas used for surgery) helps patients breathe more naturally compared to standard IV sedation. The g…

This study looks at how to best use a machine that helps people with neuromuscular disease cough and clear mucus from their lungs. Researchers will test different pressure settings to see which works best without causing side effects. About 30 adults with stable or slowly progres…

This study looks at how chronic respiratory failure affects daily life and well-being. Researchers will ask 200 patients who use breathing machines to complete quality-of-life questionnaires. The goal is to better understand the real-world impact of the condition and its treatmen…

This study looks at why people with pleural effusion (fluid around the lungs) feel short of breath. Researchers will measure breathing effort and breathlessness before and after fluid removal in 124 adults. The goal is to better understand the connection, not to test a new treatm…

This study looks at how often children develop low blood sugar (hypoglycemia) when they fast before surgery. Fasting is required to prevent choking during anesthesia, but young children have less energy stored and may be at risk. Researchers will measure blood sugar in over 6,500…

This study looks at whether a lower dose of dialysis (kidney replacement therapy) is as safe and effective as the standard dose for critically ill patients with acute kidney injury. About 20 adults in the ICU will be randomly assigned to receive either the usual dose or a lower d…

This study aims to understand the immune system's role in common lung diseases like asthma and COPD. Researchers will compare blood and airway samples from 230 adults—both healthy volunteers and those with known or suspected airway disease. The goal is to identify distinct immune…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will collect data from 120 adults in UK intensive care units to understand current practices. They will then work with patients, f…