Guy's And St Thomas' Nhs Foundation Trust

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study looks at 50 children in intensive care with severe lung infections. It uses a new method to find out which bug is actually making them sick by measuring the body's response in lung fluid. The goal is to give the right antibiotics only to those who need them, reducing s…

This study looks at two newer types of pacemakers—left bundle branch area pacing and leadless pacing—to see how they impact heart function and the tricuspid valve during the implantation procedure. Researchers will measure changes in heart pumping ability and valve leakage in 20 …

This study tests a small, smartphone-sized device called Seismofit that measures heart vibrations to estimate fitness in just three minutes. Researchers want to see if it can predict complications like pneumonia and hospital stay length in 164 oesophageal cancer patients undergoi…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study looks at how anxiety and depression influence the way older patients (65+) with critical limb threatening ischaemia make decisions about their treatment. Researchers will interview patients, their carers, and healthcare staff to understand the shared decision-making pr…

This study aims to understand why ethnic minority groups are not using genomic medicine services as much as others. Researchers will interview 100 people, including community members, patients, and healthcare professionals, to hear their experiences and ideas. The goal is to reco…

This study will interview 80 pregnant or postnatal women who have two or more long-term health conditions, along with their midwives and other healthcare professionals. The goal is to understand their experiences with midwifery care and use those insights to create better guidanc…

This study will interview 15 parents or guardians of children with spinal muscular atrophy type 1 (SMA1) to learn about their daily experiences with feeding and communication. Even though newer medicines have improved survival, how they affect swallowing and speech is still uncle…

This study looks at whether two common anti-clotting drugs, aspirin and clopidogrel, can reduce inflammation in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure how these drugs affect clusters of blood cells called monocyte…

This study looks at whether a protein called Dickkopf 3 (DKK3) in urine can warn of kidney transplant problems sooner than current blood tests. Researchers will collect urine samples from 258 kidney transplant recipients over 12 months and compare the new test with standard kidne…

This study will compare two medical devices, the Tydeman Tube and the Fetal Pillow, used to help deliver a baby when the head is stuck deep in the pelvis during a C-section. Researchers will observe 80 women having a C-section to see which device works faster and safer. The goal …

This study is testing whether a detailed health assessment designed for older adults (called KT-CGA) can improve how kidney transplant decisions are made. About 50 people aged 60 and older with advanced kidney disease will either receive this assessment plus usual care, or usual …

This study looks at why people with hypertrophic cardiomyopathy (thickened heart muscle) often get atrial fibrillation (a type of irregular heartbeat) and why it's harder to treat. Researchers will study electrical signals and images of the heart in 40 adults with both conditions…