Fred Hutchinson Cancer Center

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This study tested a digital chatbot called QuitBot to see if it could help people stop smoking. Over 1,600 adult smokers who wanted to quit were randomly assigned to use QuitBot or another program. The main goal was to see how many people had not smoked for at least 30 days after…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…

This phase 2 trial looked at whether giving a JAK inhibitor (ruxolitinib) before a donor stem cell transplant helps people with myelofibrosis. The study enrolled 61 patients with primary or secondary myelofibrosis. The goal was to see if this approach improves survival and reduce…

This phase 2 trial tested a combination of treosulfan, fludarabine, and rabbit antithymocyte globulin before a bone marrow transplant in 40 people with bone marrow failure diseases like Diamond-Blackfan anemia and Shwachman-Diamond syndrome. The goal was to see if this conditioni…

This study tested whether giving two drugs—ixazomib and lenalidomide—in an alternating schedule after a stem cell transplant could safely delay the return of multiple myeloma. Thirty patients who had already received a transplant took part. The main goal was to check for side eff…

This pilot study tested whether a diet and exercise program could prevent or reduce metabolic side effects like insulin resistance and weight gain in 20 men with prostate cancer receiving hormone therapy and radiation. Participants followed dietary instructions and did aerobic an…

This phase 2 trial tested whether anakinra, a drug normally used for rheumatoid arthritis, can prevent two serious side effects of CAR-T cell therapy: cytokine release syndrome (CRS) and nerve damage. The study enrolled 27 adults with B-cell non-Hodgkin lymphoma who were receivin…

This study tested a program designed to make HIV testing easier for men who have sex with men (MSM) in Lima, Peru. The program offered HIV testing at venues where people meet for sex, along with a text-messaging app that provides information and support. Researchers enrolled 161 …

This study tested whether providing HIV prevention pills (PrEP and PEP) at local pharmacies in Kenya helps more people start and continue taking them, compared to the usual clinic referral. Over 5,800 participants from 60 pharmacies were involved. The goal was to see if pharmacy-…

This study tested a new way to help young women in Kenya start PrEP, a daily pill that prevents HIV. Young women already taking PrEP were trained to refer their friends and give them HIV self-test kits. The goal was to see if this peer-led approach could increase PrEP use among t…

This study looked at whether following a healthy diet based on the Alternative Healthy Eating Index (AHEI) for 12 weeks could reduce pain and improve quality of life in women with endometriosis. 109 women with confirmed endometriosis and significant pain took part. Researchers me…

This study tested a smartphone app designed to help young cancer survivors (ages 15-29) manage anxiety. The app uses attention bias modification (ABM) to retrain how the brain reacts to stressful triggers, along with gratitude exercises. The goal was to see if survivors would use…

This pilot study tested a program called GUIDE, which uses a trained navigator to help cancer patients overcome social and financial barriers to joining clinical trials. The study included 100 adults with cancer who were eligible for a trial and had at least one health-related so…

This study tested a simple checklist tool to help people with sarcoma think about and plan for their future mobility needs, like getting around the house or dressing. 27 patients and their caregivers used the checklist after limb-saving or amputation surgery. The goal was to see …

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study tested a website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients took part to see if the tool reduced distress and improved planning. The goal was to learn whethe…

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…

This study followed 267 adults who had stem cell transplants to understand why some develop chronic graft-versus-host disease (GVHD), a common complication. Researchers collected blood, saliva, tears, and tissue samples, along with eye scans and breathing tests, to find early sig…

This completed phase 1 trial gave the rabies vaccine to 49 people who had previously received CAR-T therapy for B-cell cancers, along with healthy volunteers for comparison. The goal was to see if their immune systems could mount a normal response to a vaccine. By measuring rabie…

This study tested a program called PLAN to help Latino cancer patients plan for their future medical care. Twenty-seven patients with advanced cancer took part. The program aimed to improve their understanding and communication about advance care planning with doctors and family.…

This pilot study tested whether a plant-based whole-foods meal delivery service is practical for multiple myeloma patients receiving an autologous stem cell transplant. The goal was to see if patients would eat the meals and if it could improve gut microbiome diversity, which is …