New study tracks clues to predict transplant complication

NCT ID NCT04188912

Completed Knowledge-focused Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 267 adults who had stem cell transplants to understand why some develop chronic graft-versus-host disease (GVHD), a common complication. Researchers collected blood, saliva, tears, and tissue samples, along with eye scans and breathing tests, to find early signs of the condition. The goal is to help doctors predict and detect chronic GVHD sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict and catch chronic GVHD earlier after stem cell transplants.
What could go wrong: This is an observational study, not testing a treatment. It may not lead to direct improvements for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, 98109, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
National Cancer Institute

Bethesda, Maryland, 20892, United States
Roswell Park

Buffalo, New York, 14263, United States
University of Florida

Gainesville, Florida, 32610, United States
Vanderbilt

Nashville, Tennessee, 37212, United States

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