SYSTEMIC SCLEROSIS (SSC)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine triggers a good immun…

This early-stage study tests the safety of a new drug called CC312 in up to 18 adults with autoimmune diseases like lupus or rheumatoid arthritis that haven't improved with standard treatments. CC312 works like a bridge, guiding the body's immune cells to attack and destroy fault…

This early-stage study is testing a new treatment using specially engineered immune cells (CAR-T cells) in 11 children with severe rheumatic diseases like juvenile dermatomyositis, arthritis, and scleroderma that haven't responded to standard therapies. The goal is to see if thes…

This early-stage trial tests a new mRNA drug called MTS109 in 15 people with moderate to severe autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. The main goal is to see if the treatment is safe and tolerable. Researchers will also check if it helps control the…

This early-stage trial tests an experimental treatment called QEL-005 in 16 adults with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetical…

This early-stage study tests a new cell therapy called FT819 in people with moderate-to-severe autoimmune diseases like lupus, vasculitis, myositis, and scleroderma. The goal is to see if it is safe and can reduce disease activity by targeting faulty B-cells. About 244 participan…

This study tests an investigational drug called efgartigimod in 81 adults with systemic sclerosis (scleroderma), a disease that causes skin thickening and organ damage. Participants receive either the drug or a placebo for up to 48 weeks. The main goal is to see if the drug reduc…

This early-stage study is testing a new treatment called CT1190B CAR-T cell therapy in 27 adults with severe lupus or sclerosis that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and calm the overactive immune system. T…

This early-stage study is testing a new treatment for autoimmune diseases like lupus, kidney disease, and scleroderma. It uses specially engineered immune cells (CAR T-cells) from a healthy donor to target and calm the overactive immune system. The main goal is to check safety an…

This study tests a new treatment using specially engineered immune cells (CAR T-cells) that target two proteins, CD19 and BCMA, found on faulty immune cells. The goal is to see if it is safe and can help control severe autoimmune diseases like lupus and scleroderma that have not …

This study tests an experimental drug called tibulizumab in 80 adults with systemic sclerosis (scleroderma), a disease that causes skin thickening and can damage internal organs. For the first 24 weeks, some participants get the drug and some get a placebo, without knowing which.…

This early study tests a new cell treatment called YTS109 in 18 adults with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard care. Participants get a single infusion of these specially designed cells. The main goal is to see if the treatme…

This early-phase study tests a new treatment for children with severe systemic sclerosis (scleroderma) that hasn't responded to standard drugs. Doctors will give patients a single infusion of their own immune cells that have been reprogrammed to target and destroy faulty B cells.…

This study tests a new treatment using specially engineered immune cells (CAR-NK) for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't responded to standard therapies. The treatment aims to control the overactive immune system and reduce…

This study tests a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, and scleroderma) that have not responded to standard therapies. The treatment combines AlloNK, a type of immune cell from donated cord blood, with ritu…

This early-phase study tests a new treatment called TI-0032-III for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment uses a special injection to create CAR-T cells inside the body, which then target a…

This early-phase study tests a new treatment called OL-CD19-GDT, which uses specially engineered immune cells (CAR-T cells) from a healthy donor to target and destroy faulty immune cells in people with severe, treatment-resistant autoimmune diseases like systemic sclerosis and Sj…

This early-stage study tests a new treatment called QT-219C, which uses specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells that cause autoimmune diseases like lupus and kidney disease. The treatment involves a one-time infusion after a short chem…

This study is testing a new blood test that may help doctors choose the most effective drug for each person with rheumatic diseases like rheumatoid arthritis or lupus. The test looks at how a person's immune cells react to different medications before treatment starts. The goal i…

This study is testing whether injecting sodium thiosulfate directly into painful calcium deposits under the skin can shrink them and ease symptoms. It includes 20 adults with scleroderma, dermatomyositis, or mixed connective tissue disease who have calcium buildup. Participants r…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves physical function, skin health, and overall well-being. Participants are randomly assigned to BETY or standard care, and outcomes are meas…

This study tests a lotion made with hemp extract (CBD) and urea to see if it can reduce itching, improve skin moisture, and help people with scleroderma sleep better. About 36 adults with scleroderma and chronic itching will use either the CBD lotion or a plain urea lotion, then …

This study tests whether injecting a person's own fat-derived cells into their fingers can improve hand function in systemic sclerosis, a disease that causes skin hardening and hand disability. About 48 adults with moderate to severe hand stiffness will be randomly assigned to re…

This study tests whether three different diets can reduce bloating and other stomach issues in people with systemic sclerosis (scleroderma). Sixty participants will be randomly assigned to a low FODMAP diet, a CDED diet, or standard NICE dietary advice. The goal is to find which …

This study tests if a wearable device called Apollo Neuro can help people with systemic sclerosis (a chronic autoimmune disease) feel less tired and have fewer Raynaud's attacks (where fingers turn white or blue in the cold). About 160 adults will use the device or a placebo vers…

This study tests whether artificial intelligence (AI) can help doctors find a serious lung condition called pulmonary arterial hypertension (PAH) earlier in people with systemic sclerosis (scleroderma). Researchers will compare AI-based screening to traditional methods in 350 adu…

This study aims to find a way to predict serious side effects from cancer immunotherapy. Researchers will measure substances called interferons in the blood of 300 cancer patients starting immunotherapy and 40 people with autoimmune diseases like lupus. By comparing these groups,…

This study translates and tests a questionnaire called PASTUL, which helps people with scleroderma check the thickness of their skin on their arms and hands. Researchers will work with 50 Turkish-speaking adults who have scleroderma to make sure the Turkish version is accurate an…

This study aims to understand the link between nutrition and disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will assess the nutritional status of 460 participants using various scores and check if better n…

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This study looks at how scleroderma affects chewing and swallowing in both children and adults. Researchers will measure things like mouth opening, swallowing ability, and eating performance using simple tests and questionnaires. The goal is to better understand these problems an…

This study looks at how physical, mental, and social factors affect movement and daily activities in people with scleroderma. Researchers will test walking, stair climbing, and other tasks in 50 children and adults. The goal is to find better ways to measure physical function and…

This study aims to develop a better way to measure calcium deposits under the skin (calcinosis) in people with scleroderma using CT scans and special software. Researchers will compare the CT measurements with patient surveys about pain and disability. The goal is to create a too…