RENAL IMPAIRMENT

This study tested whether using a very small amount of dye during procedures to open blocked leg arteries is safe and effective for patients who also have poor kidney function. The goal was to perform the artery-opening procedure successfully while using as little dye as possible…

This study tested whether a special type of MRI scan could be a better tool for checking kidney function in people with metabolic syndrome. It compared scan results from 46 people with metabolic syndrome to those from healthy individuals. The goal was to see if this scan could de…

This early-stage study aimed to understand how a new drug, MBX 2109, behaves in the body and how safe it is. It involved 25 adults, some with healthy kidneys and some with varying degrees of kidney impairment. Each participant received a single injection of the drug so researcher…

This study followed 215 newly diagnosed HIV patients in Hong Kong for up to 5 years to understand the long-term health effects of different HIV medications. Researchers tracked conditions like high blood pressure, diabetes, bone loss, and kidney problems that can develop alongsid…

This early study tested how a single dose of an experimental drug called olpasiran behaves in people with different levels of kidney function. It involved 33 adults, some with healthy kidneys and others with mild to severe kidney problems, including some on dialysis. The main goa…

This study aimed to understand how a tuberculosis drug called pretomanid is processed by the body in people with different levels of kidney impairment. It involved 12 participants, including healthy volunteers and people with mild to severe kidney problems. Researchers gave a sin…

This early-stage study tested how the experimental drug AZD4144 behaves in people with different levels of kidney function compared to healthy volunteers. Researchers gave a single dose to 41 participants, including people with mild to severe kidney impairment and those on dialys…

This early-stage study tested how kidney function affects how the body processes ESK-001, an experimental oral drug. Researchers gave a single dose to 16 participants with varying levels of kidney function and healthy volunteers. The main goal was to measure drug levels in the bl…

This early-stage study tested how a single dose of an experimental drug, AZD6234, is processed by the body in people with different levels of kidney problems. Researchers compared 24 people with mild to severe kidney impairment, including some on dialysis, to healthy volunteers. …

This study looked at how a new weight management drug called petrelintide is processed by the body in people with different levels of kidney function. Researchers gave a single dose to 39 adults, some with normal kidneys and some with mild, moderate, or severe kidney impairment. …

This study tested how a new medicine for obesity and liver disease behaves in people with different levels of kidney function. Researchers gave a single injection to 42 adults, comparing those with healthy kidneys to those with mild, moderate, or severe kidney problems. The goal …

This early-stage study tested how a drug called resmetirom, which is being developed for liver disease, is processed by the body in people with severe kidney impairment. Researchers gave the drug for 6 days to 28 participants—half with severe kidney problems and half with healthy…

This study aimed to understand how a drug called MCI-186 is processed by the body in people with mild or moderate kidney problems compared to people with normal kidney function. It involved 30 participants who received a single dose of the drug. The main goal was to gather inform…

This study aimed to understand how moderate to severe kidney problems affect how the body processes an experimental drug called MK-8527. It involved 18 people, some with kidney impairment and some with healthy kidneys, who each received a single dose. Researchers measured how muc…

This early study aimed to understand how a drug called BPN14770 is processed by the body in people with severe kidney impairment. It compared 14 participants—some with healthy kidneys and some with severe kidney problems—to see how the drug's levels in the blood differed between …

This early study aimed to understand how a single dose of an experimental drug, AZD5462, is processed by the body in people with moderate to severe kidney problems. It compared 16 participants with reduced kidney function to healthy volunteers to check for safety and see if the d…

This study aimed to understand how a drug called calderasib (MK-1084) behaves in people with moderate to severe kidney problems compared to healthy people. Researchers gave a single dose to 34 participants and measured drug levels in their blood and urine over time. The goal was …

This early-stage study tested how a single dose of an experimental drug, BMS-986278, is processed by the body in people with different levels of kidney function. It involved 27 participants, including healthy volunteers and people with severe kidney disease or kidney failure requ…

This study aimed to understand how a drug called cenerimod is processed by the body in people with severe kidney impairment. It compared 16 participants—some with healthy kidneys and some with severe kidney problems—after they took a single dose. The main goal was to check safety…