Kidney health may change how body handles experimental drug ESK-001
NCT ID NCT06962774
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of ESK-001, an experimental drug. Sixteen participants with healthy kidneys or mild, moderate, or severe kidney impairment each took one oral dose. Researchers measured drug levels in the blood and monitored for side effects to understand how the kidneys impact the drug's breakdown and removal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ESK-001
What this could lead to
If successful, this study will help determine the right dose of ESK-001 for people with kidney problems, making future treatments safer and more effective.
What could go wrong
This is a very early, small study (16 people) focused on drug levels, not on treating any disease. It only looks at a single dose, so long-term effects or benefits are unknown.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Pharma CR
Miami, Florida, 33147, United States
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Floridian Clinical Research
Miami Lakes, Florida, 33016, United States
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Orlando Clinical Research Center
Orlando, Florida, 32809, United States
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Panax Clinical Research
Miami Lakes, Florida, 33014, United States