POSTOPERATIVE COMPLICATIONS

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This trial tests whether preserving the hernia sac as a living flap and stitching it under the mesh can reduce wound and mesh problems after complex ventral hernia repair where the defect has a bony edge. Half of the 180 participants will receive the standard repair plus the sac …

This trial tests whether closing the surgical wound immediately after cleaning it with a special high-pressure irrigation technique (HIEDI) is as good as or better than waiting a few days to close it. The study involves 200 people aged 12 and older who have open surgery for compl…

This study tests whether applying vancomycin powder directly into the surgical wound during shunt placement can prevent infections in children with hydrocephalus. About 164 children will be randomly assigned to receive either standard care or standard care plus the powder. The go…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This study tests a surgical technique done at the same time as breast cancer lymph node removal to prevent arm lymphedema (chronic swelling). The procedure uses a small flap of tissue from the side of the chest to rebuild the armpit area and support fluid drainage. One hundred hi…

This study looks at whether removing the chest tube right after lung surgery (called a tubeless strategy) helps patients recover faster with less pain. About 300 adults having a specific type of lung surgery will be randomly assigned to one of three groups: standard chest tube, o…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

This study looks at whether nutritional risk and muscle thickness can help predict recovery in adults aged 65 and older after hip fracture surgery. Researchers will measure nutritional status using a standard score and check muscle thickness in the thigh with a quick, painless ul…

This study looks at whether the biological age of a person's blood vessels, measured before heart surgery, can help predict their risk of acute kidney injury afterward. Researchers will assess vascular aging using noninvasive tests and routine lab results in about 470 adults unde…

This study looks at how different types of bilateral breast reconstruction affect women's quality of life and satisfaction. Researchers will compare women who had preventive mastectomy (due to high risk) with those who had therapeutic mastectomy (due to cancer), and also consider…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study observes 800 adults who need breathing help after major non-cardiac surgery and are moved from the operating room to the ICU. Researchers will compare manual bag ventilation versus portable ventilator use during transport, tracking vital signs and complications. The go…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a virtual, home-based prehabilitation program is practical for adults awaiting major elective surgery. About 120 participants will be randomly assigned to either the program (exercise, nutrition, mindfulness, and protein supplements) or standard car…

This study will observe 1000 adults having planned brain surgery to see if the thickness of their blood during the operation is linked to problems like infections, kidney injury, or death within 30 days. Researchers will measure blood viscosity and oxygen levels in the brain. The…

This study looks at a new way to close the belly wall during large hernia surgery to prevent breathing problems right after the operation. Doctors will use standard breathing measurements during surgery to decide the best closure method. The study will include 50 adults who are a…

This study will create a tool to predict complications after major surgery in people aged 65 and older. Researchers will collect information on physical activity, nutrition, mood, and body composition from 520 participants before surgery. The goal is to help doctors better identi…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study will look back at the records of 1,000 surgery patients who were admitted to the intensive care unit (ICU) in Villavicencio, Colombia, between 2022 and 2024. The goal is to understand what patient and surgery factors are linked to worse outcomes, such as death in the I…