LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA explained in plain language.
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New combo targets tough pancreatic tumors
Disease control Recruiting nowThis study tests a drug called M3814 combined with a special type of radiation for people with locally advanced pancreatic cancer (cancer that has spread nearby but not to distant organs). The goal is to find the safest dose and see if the combination helps stop tumor growth long…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New hope for tough pancreatic cancer: targeted drug combo under study
Disease control Recruiting nowThis study tests whether adding a targeted drug called panitumumab to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or can't be removed will be randomly assigned to get c…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New hope for tough pancreatic cancers: drug combo aims to shrink tumors before surgery
Disease control Recruiting nowThis early-phase trial tests a new drug called PTM-101 given alongside standard chemotherapy for people with pancreatic cancer that is either borderline resectable or locally advanced (meaning it has not spread far but is hard to remove surgically). The goal is to see if adding P…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: PanTher Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New chemo cocktail aims to shrink pancreatic tumors
Disease control Recruiting nowThis study compares two chemotherapy regimens for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. One group gets NALIRIFOX (a mix of four drugs) every two weeks, while the other gets a modified version of gemcitabine, nab-paclitaxel, and ci…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New combo therapy aims to boost radiation for tough pancreatic tumors
Disease control Recruiting nowThis early-phase trial tests a drug called XER-001 (a form of amifostine given through a tube into the small intestine) combined with precise radiation therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study will enroll 36 participa…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Xerient Pharma • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New 'See and Treat' combo targets tough pancreatic cancer
Disease control Recruiting nowThis early-phase study tests a two-part approach for people with advanced pancreatic cancer. First, a special scan identifies cancer cells. Then, a targeted radioactive treatment is given to destroy those cells. The goal is to check safety and find the right dose in 30 participan…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: EARLY_PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New radiation boost aims to fight pancreatic cancer
Disease control Recruiting nowThis phase 2 trial is testing whether high-dose radiation therapy, given after initial chemotherapy, can improve outcomes for people with locally advanced pancreatic cancer. About 43 participants whose tumors responded to chemotherapy will receive targeted radiation. Researchers …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Sound waves boost chemo attack on tough pancreatic tumors
Disease control Recruiting nowThis study tests whether adding Acoustic Cluster Therapy (ACT) to standard chemotherapy can shrink inoperable pancreatic tumors. About 25 adults with locally advanced pancreatic cancer will receive both treatments. The goal is to see if the combination improves response rates and…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: EXACT Therapeutics AS • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New chemo sequence aims to make pancreatic tumors operable
Disease control Recruiting nowThis phase 2 trial is testing whether giving two different chemotherapy regimens one after the other can shrink pancreatic tumors that are borderline or locally advanced, making them easier to remove surgically. The study enrolls 64 adults with pancreatic adenocarcinoma. Particip…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Can a Plant-Based compound stop deadly clots in pancreatic cancer?
Disease control Recruiting nowThis Phase 3 trial tests whether Kinisoquin™, a supplement-like drug made from isoquercetin plus vitamins C and B3, can prevent dangerous blood clots in 480 people with advanced pancreatic cancer. Participants receive either Kinisoquin™ or a placebo alongside their first chemothe…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: Quercis Pharma AG • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Electric field therapy plus radiation: new hope for pancreas cancer?
Disease control Recruiting nowThis clinical trial is testing whether adding a device that delivers low-intensity electric fields (Tumor Treating Fields) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants will receive radiation for five days and us…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: NA • Sponsor: Baptist Health South Florida • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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New gene therapy tackles tough pancreatic cancer
Disease control Recruiting nowThis early-stage trial tests a new cell-based gene therapy called RR001 given after chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study aims to check safety and find the best dose in a small group of 9 participants. It is n…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: EIR Biotherapies s.r.l. • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New cocktail of chemo and precision radiation aims to tame pancreatic cancer
Disease control Recruiting nowThis phase 2 trial tests a two-step approach for people with locally advanced pancreatic cancer that cannot be removed by surgery. First, patients receive two powerful chemotherapy regimens in sequence (GEMBRAX then FOLFIRINOX). Then, those whose cancer does not worsen get MRI-gu…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Zapping tumors with electricity: a new hope for pancreatic cancer?
Disease control Recruiting nowThis early-stage trial tests a procedure called irreversible electroporation (IRE), which uses electric pulses to destroy tumor cells, combined with standard chemotherapy drugs (gemcitabine or FOLFIRINOX). The study includes 20 adults with stage III pancreatic cancer that hasn't …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: University of Louisville • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New study explores surgery hope for inoperable pancreatic cancer
Knowledge-focused Recruiting nowThis study looks at patients with locally advanced pancreatic cancer that cannot be removed by surgery at first. After at least 4 months of chemotherapy, if the tumor shrinks enough, doctors may consider surgery. The goal is to see if this approach helps patients live longer and …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Sponsor: Azienda Ospedaliera di Padova • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC