LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA explained in plain language.
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New hope for pancreatic cancer: targeted drug combo enters phase 3 trial
Disease control Recruiting nowThis study tests whether adding the targeted drug panitumumab to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or cannot be removed will receive either chemo alone or che…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 17, 2026 02:16 UTC
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New chemo sequence aims to shrink pancreatic tumors before surgery
Disease control Recruiting nowThis study tests whether giving two different chemotherapy combinations one after the other can shrink pancreatic tumors enough to allow successful surgery. About 64 adults with borderline resectable or locally advanced pancreatic cancer will receive gemcitabine plus nab-paclitax…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated May 17, 2026 02:06 UTC
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Sound waves boost chemo against tough pancreatic tumors
Disease control Recruiting nowThis study tests whether adding Acoustic Cluster Therapy (ACT) to standard chemotherapy can shrink inoperable pancreatic tumors. ACT uses ultrasound to activate tiny gas bubbles that help chemotherapy drugs penetrate deeper into the tumor. About 25 adults with locally advanced pa…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: EXACT Therapeutics AS • Aim: Disease control
Last updated May 17, 2026 02:05 UTC
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New radiation boost may extend life for pancreatic cancer patients
Disease control Recruiting nowThis study tests whether a high-dose radiation boost after initial chemotherapy can improve outcomes for people with locally advanced pancreatic cancer that has not spread. About 43 participants will receive the radiation and complete quality-of-life surveys. The goal is to see i…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated May 17, 2026 02:04 UTC
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New combo targets tough pancreatic tumors
Disease control Recruiting nowThis study tests a drug called M3814 (Peposertib) combined with a special type of radiation for people with locally advanced pancreatic cancer that has spread to nearby tissues. The goal is to find the safest dose and see if the combination helps stop tumor growth longer than rad…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New drug aims to stop deadly clots in pancreatic cancer patients
Disease control Recruiting nowThis study tests a drug called Kinisoquin to see if it can prevent dangerous blood clots in people with advanced pancreatic cancer. About 480 adults with metastatic or locally advanced pancreatic cancer who are starting chemotherapy will receive either Kinisoquin or a placebo. Th…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: Quercis Pharma AG • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New gene therapy takes on tough pancreatic cancer
Disease control Recruiting nowThis early-stage trial tests a new cell-based gene therapy called RR001 given after chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study aims to check safety and find the best dose in about 9 participants. It is not a cure, …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: EIR Biotherapies s.r.l. • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New Dual-Action approach targets Hard-to-Treat pancreatic cancer
Disease control Recruiting nowThis early-phase study tests a two-part approach for people with advanced pancreatic cancer. First, a special imaging scan helps find tumors; then, a targeted radioactive treatment is given to try to control the disease. The study enrolls 30 adults whose cancer has spread or cann…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: EARLY_PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated May 14, 2026 12:01 UTC
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Electric fields and radiation join forces against pancreas cancer
Disease control Recruiting nowThis study tests whether adding tumor treating fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and wear a device that delivers low-intensity electric fields for at least…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: NA • Sponsor: Baptist Health South Florida • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New hope for pancreatic cancer? trial tests two drug combos Head-to-Head
Disease control Recruiting nowThis study tests two different chemotherapy combinations in people with advanced pancreatic cancer that has spread or cannot be removed by surgery. About 52 participants will be randomly assigned to receive either NALIRIFOX or a modified version of gemcitabine, nab-paclitaxel, an…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated May 12, 2026 13:44 UTC
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Light-activated therapy may boost immune attack on hard-to-treat pancreatic cancer
Disease control Recruiting nowThis study tests a new combination for people with pancreatic cancer that cannot be surgically removed. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab) plus standard chemotherapy. The goal is to see if this approach shri…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 12, 2026 13:40 UTC
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New combo therapy aims to tame tough pancreatic tumors
Disease control Recruiting nowThis early-stage study tests a drug called XER-001 given through a tube into the small intestine, combined with precise radiation, for people with locally advanced pancreatic cancer. The goal is to find the safest dose and see if the treatment can control the tumor. About 36 adul…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Xerient Pharma • Aim: Disease control
Last updated May 11, 2026 20:39 UTC
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New combo therapy aims to halt pancreatic cancer progression
Disease control Recruiting nowThis study tests a two-step chemotherapy plan (Gemcitabine/Nab-paclitaxel followed by FOLFIRINOX) and then precise MRI-guided radiation for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to stop the cancer from growing for at least 4…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle • Aim: Disease control
Last updated May 07, 2026 18:40 UTC
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New combo aims to shrink hard-to-treat pancreatic tumors
Disease control Recruiting nowThis early-phase trial tests a new drug called PTM-101 given alongside standard chemotherapy for people with pancreatic cancer that is either borderline resectable or locally advanced. The goal is to see if the combination is safe and can shrink tumors enough to allow surgery. Ab…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: PanTher Therapeutics • Aim: Disease control
Last updated May 04, 2026 16:24 UTC
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New hope for advanced pancreatic cancer: surgery after chemo shows promise
Knowledge-focused Recruiting nowThis study looks at whether surgery can be an option for people with locally advanced pancreatic cancer after chemotherapy shrinks the tumor. Researchers will track survival and quality of life in 150 patients treated at expert centers. The goal is to see if this approach helps p…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Sponsor: Azienda Ospedaliera di Padova • Aim: Knowledge-focused
Last updated May 14, 2026 12:04 UTC