LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA explained in plain language.
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Light-activated therapy may boost immune attack on hard-to-treat pancreatic cancer
Disease control OngoingThis study tests a new combination for people with pancreatic cancer that cannot be surgically removed or has spread. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab), alongside standard chemotherapy. The goal is to see i…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug combo aims to tackle pancreatic cancer in patients with inherited gene mutations
Disease control OngoingThis phase II trial is testing whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) can shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA1, BRCA2, or PALB2 gene mutations. The study has two parts: one com…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Blasting pancreatic tumors with extra radiation may open door to surgery
Disease control OngoingThis phase 2 trial tests whether giving a higher-than-standard dose of radiation, along with chemotherapy, can shrink pancreatic tumors enough to make them removable by surgery. The study includes 47 people with locally advanced pancreatic cancer that currently cannot be surgical…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Experimental vaccine targets Hard-to-Treat pancreatic cancer
Disease control OngoingThis early-phase study tested a vaccine therapy given directly into the tumor along with a growth factor to boost the immune system in 18 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the safest dose and check for side effe…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Zapping tumors: electric fields tested against pancreatic cancer
Disease control TEMPORARILY_NOT_AVAILABLEThis program gives adults with locally advanced pancreatic cancer access to a device that delivers gentle electric fields to the abdomen, combined with standard chemotherapy. The goal is to see if this approach is safe and feasible while the device awaits FDA approval. Participan…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Sponsor: NovoCure GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New cocktail aims to starve pancreatic tumors
Disease control OngoingThis early-phase trial tests two drugs together in 15 people with advanced pancreatic cancer. One drug, calaspargase pegol-mknl, lowers a nutrient that cancer cells need to grow. The other, cobimetinib, blocks a protein that helps cancer cells survive. The goal is to find a safe …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can chemo before surgery make pancreatic cancer removable?
Disease control OngoingThis study looks at whether giving chemotherapy first can shrink pancreatic tumors that have grown into nearby arteries, making them safe to remove with surgery. Researchers want to see if this approach can completely remove the cancer without leaving any behind. Only 2 people ar…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Experimental drug ampligen takes on pancreatic cancer in new trial
Disease control TerminatedThis phase 2 trial tests whether adding the experimental drug Ampligen to standard care can help people with locally advanced pancreatic cancer that hasn't spread. About 90 participants who have completed at least four months of initial chemotherapy will receive either Ampligen p…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: AIM ImmunoTech Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New scan could reveal hidden oxygen levels in pancreatic cancer
Knowledge-focused OngoingThis study explores whether a special PET-MRI scan using a tracer called FAZA can safely measure oxygen levels (hypoxia) in pancreatic tumors. About 20 adults with advanced, non-spreading pancreatic cancer will get two scans—before and after standard radiation. The goal is to see…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC