KNEE PAIN CHRONIC

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Res…

This study tested whether a health coaching program (called CAPPA) combined with a Fitbit could help employees with chronic knee pain become more physically active. Thirty-nine participants were split into two groups: one received physical activity coaching, the other received ge…

This study tested whether adding a specific massage technique (myofascial release) to standard physical therapy could improve quality of life for people with chronic knee pain. 45 adults with knee pain participated. The approach focused on a small muscle behind the knee called th…

This study tested whether taking UC-II, glucosamine, and curcumin together can reduce knee pain and inflammation. Thirty-two adults with chronic knee pain were randomly assigned to receive the supplement or a placebo for a set period. Researchers measured pain levels, knee functi…

This study tested different volumes of an ultrasound-guided nerve block (adductor canal block) to manage pain after total knee replacement. 90 adults scheduled for knee replacement under spinal anesthesia received one of two volumes. The goal was to see which volume reduces opioi…

This study tested two different nerve block methods to control pain after total knee replacement surgery. Sixty older adults (ages 65-100) received either a two-level erector spinae block or an iPack with ACB block. The main goal was to see which method reduced the need for opioi…

This study looked at whether doing ankle exercises can improve how well you sense your knee's position and reduce pain in people with long-term knee pain. 114 adults aged 18 to 70 with knee pain for at least six months took part. They did either ankle exercises or knee exercises,…

This phase 2 trial tested whether a single injection of TTAX03, made from human amniotic and umbilical cord tissue, can reduce pain and improve function in people with advanced knee osteoarthritis (grades 3-4). 90 adults received either TTAX03 or a saline placebo, and researchers…