KIDNEY TRANSPLANTATION

This early-phase study tested a new approach to help kidney transplant recipients reduce or stop their lifelong anti-rejection medications. Eight adults received donor stem cells along with a combination of immune-suppressing drugs. The goal was to see if this treatment could saf…

This study tested a new drug combination in 20 kidney transplant recipients to see if it could prevent organ rejection without using steroids or certain standard drugs. Participants received two antibody infusions right after transplant, then took only one maintenance drug (tacro…

This pilot study tested whether a single dose of tocilizumab, given right before or after removing a failed kidney transplant, is safe and can lower the level of harmful antibodies that make a second transplant difficult. 18 adult patients who needed graft removal and planned to …

This study tested a new medicine called CFZ533 to see if it could prevent the body from rejecting a donated kidney. About 418 kidney transplant patients took part. The goal was to compare CFZ533 to the standard drug tacrolimus in keeping the new kidney working and preventing reje…

This study looked at kidney transplant patients who already had one skin cancer. It compared switching their anti-rejection medicine to rapamycin versus staying on standard drugs. The goal was to see if rapamycin could prevent new skin cancers over two years. The study included 7…

This study looked at whether adjusting the dose of the anti-rejection drug tacrolimus based on a patient's genetic makeup could help achieve better drug levels in the blood after a kidney transplant. About 280 adult kidney transplant recipients took part. Researchers compared sta…

This study tested a new combination of two drugs (belatacept and a proteasome inhibitor) in 5 highly sensitized kidney transplant candidates. The goal was to lower their strong immune antibodies so they could find a compatible donor and receive a transplant. The approach aims to …

This study tested a new approach for people receiving a kidney from a matched sibling. Doctors gave donor stem cells along with the transplant, aiming to train the body to accept the new kidney without needing lifelong anti-rejection drugs. The goal was to safely stop all immunos…

This study tested a single dose of a new drug called ASKP1240 in 50 people who just received a kidney transplant. The goal was to see how the drug moves through the body, how safe it is, and how well it works. Participants were randomly assigned to get the drug or a placebo, and …

This study tested switching children who had stable organ transplants from one immunosuppressant (Prograf) to a longer-acting version (Advagraf). The goal was to compare drug levels in the body and monitor safety and effectiveness over one year, with extended follow-up. 81 childr…

This study looked at whether two diabetes drugs, metformin and empagliflozin, can safely improve metabolic problems (like unhealthy fat buildup and blood sugar issues) in people who have had a kidney transplant. 105 kidney transplant recipients with good kidney function were rand…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study looked at whether giving kidney transplant patients a lower dose of the anti-rejection drug cyclosporine, along with another drug called mycophenolate mofetil, could help protect their kidney function over two years. The study involved 208 adults who had received a kid…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could prevent the body from rejecting the kidney as well as or better than current standard treatments. Participants received different combinations of drugs, and r…

This study looked at whether analyzing proteins in kidney biopsy samples can better detect early signs of rejection after a transplant. Researchers studied 141 kidney transplant recipients to see if a protein signature could identify microvascular inflammation, a key sign of anti…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested whether giving intravenous immunoglobulins (IVIG) can prevent BK virus infection after a kidney transplant. The virus can damage the new kidney in up to 10% of patients. 359 adults with low protective antibodies against the virus received either IVIG or no extra…

This study tested a special stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if the stent could be removed in a clinic without general anesthesia, making the process easier and less scary for kids. The approach worked…

This study looked at whether a simple urine test could predict kidney scarring (fibrosis) after a kidney transplant, instead of using a needle biopsy. Researchers measured certain genetic markers in the urine of 300 kidney transplant recipients over the first year after surgery. …

This study followed 72 kidney and lung transplant patients for one year to see how their hand tremors changed over time. Tremors are a common side effect of the anti-rejection drugs (calcineurin inhibitors) that patients must take. Researchers used spiral drawings and wrist-worn …

This early-stage study tested a new drug, SHR-2106, in 52 healthy adults to see if it is safe and how the body processes it. Participants received a single dose either through a vein or under the skin. The goal was not to treat any disease, but to gather important safety informat…

This study looked at 24 kidney transplant recipients to see if substances measured in a small piece of the donor kidney could predict how well the organ would work. Researchers tested blood, urine, and biopsy tissue to find risk factors for early organ problems or rejection. The …

This study tested a decision-making tool for people waiting for a kidney transplant. 100 participants used an online education tool and discussed their options with a doctor. The goal was to see if the tool helps patients feel more prepared and confident when deciding whether to …

This study looked at 241 kidney transplant patients to see how certain antibodies (AT1R-Ab) change before and after transplant. Researchers measured these antibodies over one year to understand their link to kidney function and organ survival. The goal is to help doctors better p…

This study looked at 50 people who had a pancreas-kidney transplant to understand how the surgery changes bile acids and blood sugar control. Researchers measured bile acid levels and glucose tolerance one year after transplant. The goal was to learn why some patients still have …