HEALTHY ADULTS

This study tested an inhaled drug called treprostinil in people with high blood pressure in their lungs caused by scarring lung disease. Researchers wanted to understand how the drug helps during exercise and affects quality of life after three months of use. The study involved 2…

This study tested a new home device that uses a special mouthwash and blue light to kill bacteria in dental plaque. Researchers wanted to see if using this light treatment along with regular brushing and flossing cleaned teeth better than just brushing and flossing alone. The stu…

This study tested whether a chicken extract supplement could improve mental energy, including feelings of fatigue, vigor, and motivation, in healthy adults. Researchers enrolled 189 participants who reported poor sleep quality and randomly assigned them to receive either the supp…

This study tested whether daily omega-3 fish oil supplements could help adults who feel highly stressed or anxious. For three months, 64 participants took either omega-3 capsules or a placebo pill, without knowing which one they received. The results suggest that those taking ome…

This study aimed to understand how bismuth subsalicylate (BSS), the active ingredient in medicines like Pepto-Bismol, affects the community of bacteria living in a healthy person's gut. Thirty-four healthy adults took BSS for two days, and researchers collected stool samples befo…

This early Pfizer study tested how two common medicines—an immunosuppressant and an antibiotic—affect the way the body processes a new drug called PF-07328948. It involved 26 healthy adult volunteers who stayed in a clinic to have their blood levels and safety monitored. The goal…

This early-stage study aimed to understand how carbamazepine, an existing medication, changes how the body processes an experimental drug called PF-07220060. It involved 14 healthy adults who took both drugs in a specific sequence. Researchers measured drug levels in the blood to…

This study aimed to understand how the body absorbs, processes, and eliminates the experimental drug PF-07104091. It involved 9 healthy adult men who took the drug by mouth and also received a tiny, traceable intravenous dose. Researchers measured how much of the drug entered the…

This early-stage study aimed to check if a compound called CHI-554 is safe to take when someone also drinks alcohol. Researchers enrolled 29 healthy adults to monitor for side effects and changes in vital signs and liver health. The goal was to gather basic safety information, no…

This study aimed to understand how the body absorbs and processes four different versions of a dietary supplement ingredient called Urolithin A (Mitopure). It involved 48 healthy adults who each received a single dose of one formulation. Researchers measured the ingredient's leve…

This study aimed to understand how two different tablet versions of an experimental Pfizer drug (PF-07248144) are absorbed by the body. It involved 24 healthy adults who took single doses of a coated and an uncoated tablet. The main goal was to compare the drug levels in the bloo…

This study tested whether a special video game that combines physical movement with mental challenges could improve attention and memory in healthy adults. Researchers at UCSF enrolled 49 participants who trained for eight weeks using different versions of the game. The goal was …

This study tested how a new drug called KP-001 is processed by the body in people with different levels of liver problems. Researchers gave a single dose to 24 adults, including healthy volunteers and people with mild to severe liver impairment. The goal was to see if liver probl…

This study investigated how different intensities of exercise affect the brain and body's stress response. Researchers had 24 adults with mild stress symptoms complete three sessions: moderate cycling, vigorous cycling, and seated rest. They measured brain blood flow during memor…

This study aimed to find better, more objective ways to measure what people eat by looking for chemical traces left by specific foods. Researchers fed 30 healthy adults controlled diets containing foods like beef, beans, and eggs in a specific sequence. They then analyzed partici…

This was a long-term research project that followed over 5,000 German adults aged 55 to 70 for a decade. The goal was to understand how the transition into retirement affects people's physical activity, feelings of loneliness, and overall well-being. Researchers conducted surveys…