HEALTHY ADULTS

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This completed study tested whether a daily prebiotic supplement called SuperHMO, made from sugars found in breast milk, could improve gut health in healthy adults. Thirty-two participants took either the supplement or a placebo for 30 days. Researchers measured changes in gut ba…

This study tested a home-use dual-light device designed to kill bacteria and reduce dental plaque. Twenty healthy adults used the device along with their regular oral care routine. The goal was to see if the light treatment could remove more plaque than brushing and flossing alon…

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This completed trial tested whether a chicken extract supplement can improve mental energy—like reducing fatigue and boosting focus—in healthy adults aged 35 to 64. Participants took a high or low dose of the supplement or a placebo daily for two weeks. The study measured attenti…

This study tested whether daily omega-3 supplements (fish oil) can help reduce stress, anxiety, depression, and improve memory and sleep in 64 Saudi adults who reported high stress. Participants took either omega-3 or a placebo for three months. Those taking omega-3 reported lowe…

This study compares two passive warm-up methods—infrared heating and therapeutic massage—to see which one improves balance and jump performance better. One hundred healthy adults aged 18-35 will do a short cycling warm-up followed by either infrared or massage, then be tested on …

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This completed Phase 1 study tested how the antifungal drug fluconazole changes the way the body processes an experimental drug called PF-07248144. Twelve healthy adults took PF-07248144 alone and then again with fluconazole. Researchers measured drug levels in the blood to under…

This study looked for substances in blood and urine that can show what a person has eaten, instead of relying on memory or food diaries. Thirty-two healthy adults ate specially prepared meals for a week, and researchers tested their blood, urine, and stool samples. The goal was t…

This early-stage study tested a new oral drug called PF-07940369 in 30 healthy adults to see if it is safe and how the body processes it. Participants took the drug or a placebo once or twice daily for 14 days while staying at a clinic. The main goal was to check for side effects…

This study looked at how two common drugs (itraconazole and probenecid) change the way the body handles a new experimental medicine called PF-07220060. It involved 25 healthy adults who took the new medicine alone and then again with the other drugs. The goal was to understand po…

This study looked at how the drug carbamazepine changes the way the body handles another drug called PF-07248144. Twelve healthy adults took PF-07248144 alone and then with carbamazepine. Researchers measured drug levels in the blood to understand the interaction and check for sa…

This study looked at how bismuth subsalicylate (the active ingredient in Pepto-Bismol) changes the bacteria in the gut. 34 healthy adults took the medicine for 2 days, and researchers compared their stool samples before and after. The goal was to learn more about how this common …

This study looked for chemicals in blood and urine that can show what foods people have eaten, like beef, beans, and eggs. Thirty healthy adults ate controlled meals and gave samples over several days. The goal is to develop more accurate ways to measure diet than asking people t…

This completed Phase 1 study looked at how two common drugs—cyclosporine and clarithromycin—affect the levels of a new experimental medicine called PF-07328948 in the body. Twenty-six healthy adults received PF-07328948 alone and then with cyclosporine or clarithromycin. The goal…

This study followed more than 5,000 adults aged 55–70 over nearly ten years to learn how retirement affects loneliness, physical activity, and overall well-being. Researchers interviewed participants three times between 2013 and 2019. The goal was to gather information, not to te…

This completed Phase 1 study by Pfizer enrolled 9 healthy adult men to learn how the experimental drug PF-07104091 is absorbed, broken down, and eliminated. Participants took the drug by mouth and later received a tiny radioactive dose intravenously. The study measured how much o…

This study tested four different versions of the dietary supplement Urolithin A (Mitopure) in 48 healthy adults to see how well each is absorbed by the body. Participants took a single dose after fasting, and blood samples were collected over time. The goal was to understand whic…

This study looked at how a single session of cycling at moderate or vigorous intensity affects stress markers, inflammation, and brain activity in 24 healthy adults and those with mild stress symptoms. Participants did 20 minutes of seated rest, moderate cycling, or vigorous cycl…

This completed Phase 1 study by Pfizer enrolled 24 healthy adults to compare how two different tablet forms of the drug PF-07248144 are absorbed by the body. Participants received single doses of each form in a crossover design, with some taking the drug after eating. The goal wa…

This completed study looked at how the drug carbamazepine changes the way the body handles a new medicine called PF-07220060. Fourteen healthy adults took PF-07220060 alone and then again after taking carbamazepine for several days. Blood samples were collected to measure drug le…

This completed Phase 1 study tested a single 50 mg dose of the drug KP-001 in 24 adults, some with healthy livers and others with different levels of liver impairment. The goal was to see how liver function affects the drug's levels and safety in the body. Results could help guid…

This study tested whether a special video game that combines physical movement with mental challenges can improve attention and memory in healthy adults. 49 participants played the game for 36 minutes a day, 3 days a week for 8 weeks. The goal was to see if the combined training …

This early-stage study looked at whether taking CBD oil (CHI-554) along with alcohol is safe for healthy adults. 29 volunteers received either 50 mg CBD, 100 mg CBD, or a placebo, and researchers monitored side effects, liver function, and blood pressure. The goal was simply to c…