GINGIVITIS

This Phase 3 trial will test whether a toothpaste containing chitosan, a natural substance, can reduce plaque, gingivitis, and gum bleeding better than a standard fluoride toothpaste. About 90 adults aged 18-70 with good general health will brush with either the chitosan toothpas…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study tests whether a probiotic lozenge containing a special strain of Streptococcus salivarius (SALI-10) can reduce gum inflammation and bad breath. Sixty adults with gingivitis will take the lozenge or a placebo twice daily for four weeks. The goal is to see if the probiot…

This study is testing a mouth rinse made from stingless bee honey as a gentler alternative to standard chemical mouthwashes for gingivitis (gum inflammation). Researchers will develop the rinse, check its safety and germ-fighting power in the lab, then test it in 20 volunteers to…

This study will test if a toothpaste with stannous fluoride can reduce bacteria on teeth, tongue, cheeks, and gums better than a regular toothpaste. About 100 adults with plaque and gingivitis will brush with one of the two toothpastes. The goal is to see which one controls bacte…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests whether a special mouthwash can reduce gum inflammation (gingivitis) in adults. Thirty healthy volunteers with moderate gum redness and swelling will rinse daily for 4 weeks. Dentists will check their gums at the start and end to see if the product helps ease sym…

This study compares two ways of teaching oral hygiene to adults with braces who have gum inflammation (gingivitis). One group gets personalized training called iTOP, while the other gets standard video and model instruction. Researchers will measure plaque and gum health after th…

This study compares a homemade herbal mouthwash to chlorhexidine, the standard mouthwash for gingivitis. Gingivitis is a common gum disease caused by plaque buildup. The herbal option may have fewer side effects. The trial will include 12 adults with plaque-induced gingivitis and…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study will test three ways to clean clear aligners: brushing with fluoride toothpaste, using chlorhexidine mouthwash, or using an oxygen-based cleanser. Twenty-one adults will try each method for one month to see how it affects bacteria and gum health. The goal is to find wh…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…