GENERALIZED ANXIETY DISORDER

This study tests whether an 8-week mindful self-compassion program works as well when delivered by video as it does in person. About 80 adults with anxiety disorders or major depression will take part. The goal is to see if online delivery can reduce symptoms and improve emotiona…

This study is testing whether a self-guided internet program called Velibra can help people with anxiety disorders (like panic disorder, social anxiety, or generalized anxiety) while they wait for standard treatment. About 30 adults with these conditions will use the online progr…

This study tests whether group therapy for generalized anxiety disorder works as well as individual therapy. 64 adults with GAD will receive either group or individual metacognitive therapy. The goal is to see if group treatment can be a more accessible and cost-effective option …

This study is testing a new internet-based therapy for young people aged 8 to 17 with anxiety disorders. The therapy is a type of talk therapy called cognitive behavioral therapy (CBT), delivered online over 12 weeks. The goal is to see if it reduces anxiety severity and is helpf…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms and change brain activity in people with generalized anxiety disorder. About 46 adults will receive one of two types of touch therapy twice a week for six weeks. Brain scans and questionnaires …

This study tests a new medication called crisugabalin for people with generalized anxiety disorder. About 216 Chinese adults will receive either crisugabalin, a placebo, or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces anxiety symptoms bet…

This study compares two approaches to treating anxiety in children and teens aged 8-17. In stepped care, everyone starts with online therapy and gets in-person sessions if needed. In stratified care, participants are assigned to online or in-person therapy based on their needs. T…

This early-stage study tests whether a generative AI chatbot called Therabot-CALM is acceptable and helpful for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and survey…

This study tests a gentle, non-invasive brain stimulation method called cTBS to see if it can reduce anxiety in people with Generalized Anxiety Disorder. Forty adults will receive either real or placebo stimulation three times daily for a week. Researchers will use brain scans to…

This study tests an experimental medication called ITI-1284 for adults with generalized anxiety disorder (GAD) who haven't gotten enough relief from existing treatments. About 570 participants will receive either the study drug or a placebo, and researchers will measure changes i…

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study tests whether a single injection of RE104 can reduce anxiety symptoms in people with Generalized Anxiety Disorder (GAD). About 64 adults with GAD will receive either RE104 or a placebo, and researchers will measure anxiety levels using a standard scale after 4 weeks. T…

This study tests if a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. Participants will use an online program that teaches coping skills. The goal is to reduce heavy drinking and improve anxiety symptoms. If effective, this a…

This study tests an experimental drug called ITI-1284 in adults with generalized anxiety disorder (GAD) who still have significant symptoms despite their current treatment. About 705 participants will receive either ITI-1284 or a placebo added to their usual therapy. The goal is …

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video call, or a mix of both works better for children aged 5-18 with anxiety or OCD. About 501 participants will be randomly assigned to one of three delivery methods. The goal is to see which appr…

This study looks at how mindfulness-based stress reduction (MBSR) affects the brains of 150 adults with generalized anxiety disorder. Participants will be randomly assigned to either an 8-week MBSR program or a stress education class. Researchers will use brain scans and other te…

This study aims to understand why medical students develop depression and other mental health issues like anxiety, suicidal thoughts, and substance abuse. Researchers will follow up to 10,000 students over 22 years, comparing those who enter medical school with those who do not. …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different areas of the prefrontal cortex and test how behavior changes. The goal is to understand which brain circui…

This study tests whether giving young adults with anxiety real-time feedback on their brain activity can improve their ability to regulate emotions. About 110 participants with generalized anxiety, social anxiety, or panic disorder will either get real or fake neurofeedback durin…

This study aims to see if a carbon dioxide (CO2) breathing challenge can help predict which people with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults aged 18 to 70. If successful, this simple test could help c…

This study uses a simple survey to quickly check if people with depression, anxiety, or borderline personality disorder might qualify for future drug trials run by pharmaceutical companies. Researchers aim to enroll 20,000 adults to see how many are eligible and what conditions m…