GBM
Clinical trials for GBM explained in plain language.
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Sound waves and Light-Activated drug take on deadly brain tumors
Disease control Recruiting nowThis early-stage study tests a new treatment for glioblastoma, an aggressive brain cancer that has come back after initial therapy. The approach combines an investigational drug (5-ALA) with focused ultrasound waves guided by brain imaging to target and damage tumor cells before …
Matched conditions: GBM
Phase: PHASE1 • Sponsor: Shayan Moosa, MD • Aim: Disease control
Last updated May 17, 2026 05:26 UTC
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Virus and radiation team up against deadly brain tumors
Disease control Recruiting nowThis early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…
Matched conditions: GBM
Phase: PHASE1 • Sponsor: Henry Ford Health System • Aim: Disease control
Last updated May 17, 2026 05:06 UTC
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New hope for aggressive brain cancer: combo therapy enters phase 2 trial
Disease control Recruiting nowThis study tests whether adding silevertinib (an oral targeted therapy) to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. About 162 adults whose tumors have certain genetic markers (…
Matched conditions: GBM
Phase: PHASE2 • Sponsor: Black Diamond Therapeutics, Inc. • Aim: Disease control
Last updated May 11, 2026 20:54 UTC
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Sound wave helmet could help chemo reach brain tumors
Disease control Recruiting nowThis early-stage trial tests a special helmet that uses sound waves to temporarily open the blood-brain barrier, allowing chemotherapy to better reach aggressive brain tumors called glioblastoma. Ten adults who have already completed initial treatment will receive the helmet trea…
Matched conditions: GBM
Phase: PHASE1 • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated May 11, 2026 20:39 UTC
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New MRI technique could supercharge brain tumor treatment
Disease control Recruiting nowThis study tests a more precise way to place electrodes on the scalp for glioblastoma patients receiving Optune therapy, which uses electrical fields to kill cancer cells. By using advanced MRI to map the full extent of the tumor, researchers hope to deliver a stronger dose to th…
Matched conditions: GBM
Phase: NA • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated May 11, 2026 20:37 UTC
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Sound waves and light drug take on deadly brain cancer
Disease control Recruiting nowThis study tests a new treatment for glioblastoma, an aggressive brain cancer. It combines an investigational drug (5-ALA) with a non-invasive ultrasound device to target tumor cells. About 103 patients who have completed standard therapy will be randomly assigned to receive eith…
Matched conditions: GBM
Phase: PHASE2 • Sponsor: Alpheus Medical, Inc. • Aim: Disease control
Last updated May 04, 2026 16:22 UTC
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Sound waves open brain barrier to attack deadly tumors
Disease control Recruiting nowThis phase 3 trial tests whether a device called SonoCloud-9 can temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors in people with recurrent glioblastoma. About 560 participants will be randomly assigned to receive either carb…
Matched conditions: GBM
Phase: PHASE3 • Sponsor: CarThera • Aim: Disease control
Last updated May 01, 2026 16:00 UTC
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New hope for aggressive brain cancer: phase 3 trial launches
Disease control Recruiting nowThis study tests a new drug, niraparib, against the standard treatment temozolomide in adults with a newly diagnosed, hard-to-treat type of glioblastoma (a brain cancer). About 450 participants will be randomly assigned to one of the two drugs, taken daily during radiation. The m…
Matched conditions: GBM
Phase: PHASE3 • Sponsor: Ivy Brain Tumor Center • Aim: Disease control
Last updated Apr 29, 2026 15:02 UTC