GBM

This study tested a new surgical technique in 12 patients with newly diagnosed glioblastoma, an aggressive brain cancer. Surgeons placed a tissue flap from the scalp into the brain tumor cavity to bypass the blood-brain barrier, which normally blocks many treatments. The main goa…

This early-phase study tested whether a 4-month ketogenic diet (a high-fat, low-carb diet) is safe and doable for people with newly diagnosed glioblastoma, a serious brain cancer. Twenty-one adults followed personalized meal plans while receiving standard radiation and chemothera…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This phase 2 trial tested a drug called VAL-083 combined with standard radiation in 29 people with newly diagnosed glioblastoma, a fast-growing brain cancer. The study focused on patients whose tumors have a specific genetic marker (unmethylated MGMT) that makes them resistant to…

This study looked at whether a combination of two drugs (LY3214996 and abemaciclib) can reach brain tumors in people with recurrent glioblastoma, a type of aggressive brain cancer. About 42 participants took the drugs before surgery to remove their tumor, and researchers measured…