GBM

This study tested a drug called VAL-083 combined with standard radiation for people newly diagnosed with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the combination helps control th…

This early-phase trial tested whether adding two drugs—pembrolizumab (an immunotherapy) and vorinostat (a targeted drug)—to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. The study enrolled 21 adults and focus…

This study tested whether a 4-month ketogenic diet (high-fat, low-carb) is safe and doable for people with newly diagnosed glioblastoma, a serious brain cancer. Twenty-one adults followed personalized meal plans while receiving standard radiation and chemotherapy. Researchers tra…

This study looked at how well two drugs, LY3214996 and abemaciclib, get into the brain tumors of people with recurrent glioblastoma. About 42 participants took the drugs before surgery to remove their tumor. Researchers measured drug levels in the tumor tissue and spinal fluid to…