CHILDREN, ONLY

This study looks at two ways to clean the blood in children with sepsis, a life-threatening infection. It compares continuous blood purification (done without stopping) to non-continuous methods. The goal is to see which approach helps more children survive 28 days after leaving …

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (symptom-free and healed gut) af…

This study tests whether a virtual reality simulation that mimics an MRI scan can help children aged 4-18 stay calm enough to complete the real scan without anesthesia. About 288 children will either use the VR prep, read a booklet, or receive usual care before their MRI. The mai…

This study looks at whether inhaling isopropyl alcohol (rubbing alcohol) can reduce nausea and vomiting in children visiting the emergency room. About 84 kids aged 7 and older will be randomly assigned to get either the alcohol vapor, standard anti-nausea medicine (ondansetron), …

This study tests whether a specially designed digital game can help children aged 8-13 with type 1 diabetes improve their blood sugar control, confidence in managing their condition, and overall quality of life. About 58 children will play the game as part of their care. The goal…

This study looks at whether mat Pilates can reduce pain and improve posture in school-aged children (8-16 years) with Upper Crossed Syndrome, a condition that causes forward head, rounded shoulders, and a curved upper back. Half of the 28 participants will do mat Pilates plus rou…

This study looks at whether it's possible to track sleep and the body's internal clock in critically ill children aged 3 to 6 in the pediatric ICU. Researchers will use a watch-like device and saliva tests to measure sleep and melatonin levels. They will also test if giving brigh…

This study will follow 10,000 children with bacterial meningitis to see which bacteria are causing the disease and how well current vaccines and antibiotics are working. Researchers will track deaths and treatment failures. The goal is to improve future prevention and treatment s…

This study looks at bacteria (pneumococcus) in the noses of children with ear infections and healthy children. It aims to see if vaccines have changed which types of bacteria are common and whether they are becoming resistant to antibiotics. Over 25,000 children will be observed,…

This study looks at how two types of exercise—aerobic exercise and low-intensity interval training—affect heart and lung fitness in healthy school children aged 6 to 12. Researchers will measure fitness using a shuttle run test and estimate VO2 max. The goal is to find effective …

This study observes up to 1,900 children under 2 years old with ear infections to see how often they are caused by RSV. Researchers want to understand the burden of RSV-related ear infections, especially with or without bronchiolitis. The study does not test a new treatment but c…

This study follows 300 critically ill children who had sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term impact of this ser…