BLEEDING

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study looked at how well a gel-like material called Obsidio works to block blood vessels in people with hypervascular tumors or bleeding. 125 adults were treated, and researchers checked if the vessels were successfully blocked and if there were any serious side effects with…

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study compared two treatments for bleeding after heart surgery in children aged 2 years or younger. One group received a purified fibrinogen concentrate, the other received cryoprecipitate (a blood product). The goal was to see if the concentrate works as well as cryoprecipi…

This completed study tested two strategies to reduce bleeding and artery blockage after a common heart procedure. 451 patients received either a standard or lower dose of heparin and a different compression band. The goal was to see if the new approach could shorten recovery and …

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a new way to prevent blood clots in the dialysis machine without using heparin, a blood thinner that can cause dangerous bleeding. The method uses a special fluid with citrate and no calcium, and adds calcium back into the body as needed. The study included 97 c…

This study tested a pathogen-reduced version of cryoprecipitate, a blood product that helps blood clot, in 208 patients undergoing liver transplant or heart surgery. The goal was to see if having this product readily available could stop bleeding early and reduce the need for oth…

This study tracked 949 patients with non-valvular atrial fibrillation who received the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to reduce stroke risk. The goal was to see how well the device works in everyday medical practice, focusing on safet…

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This study tested a new dental sponge called Colibricare (Coli-sorb®) in 124 patients having their wisdom teeth removed. The sponge was compared to a standard gauze and a commercial sponge. Researchers measured how quickly bleeding stopped, pain levels, swelling, and wound healin…

This study tested whether rinsing the sinuses with hot saline (50°C) during surgery for chronic sinusitis reduces bleeding and improves the surgeon's view. 59 adults were split into three groups: hot saline, room-temperature saline, or no rinse. The goal was to see if the hot rin…

This completed study tested whether giving children the drug dexmedetomidine during tonsillectomy surgery could reduce pain and agitation afterward. 85 children aged 2-10 took part. Researchers measured pain and anxiety levels after the operation to see if the drug helped compare…

This study tested whether giving tranexamic acid (TXA) before tummy tuck surgery reduces blood loss. Sixty adults scheduled for abdominoplasty received either TXA or a placebo before their operation. Researchers measured blood loss, hemoglobin, and other markers to see if TXA hel…

This study tested whether a single dose of tranexamic acid, given before surgery, can reduce blood loss in women undergoing breast cosmetic surgery. 60 women participated, and researchers measured blood loss, hemoglobin, and other clotting factors. The goal is to see if this comm…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This study looked at whether it is safe to lower the number of platelets needed before placing a central line (a special IV) in patients with blood disorders. Normally, patients get a platelet transfusion if their count is below 50, but this study tested a lower trigger of 10. Th…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This study followed 167 people with atrial fibrillation or flutter who had a catheter ablation procedure. Researchers measured changes in stroke and bleeding risk scores before and 3, 6, and 12 months after ablation. They also compared different monitoring methods, including impl…

This study looked at 278 adults on a heart-lung support machine (VA ECMO) to find early warning signs of dangerous bleeding. Researchers collected data on patient health history, treatments, and lab results at the start of support. The goal was to identify factors that increase b…