New bleeding treatment tested in Kids' heart surgery

NCT ID NCT04376762

Completed Disease control Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two treatments for bleeding after heart surgery in children aged 2 years or younger. One group received a purified fibrinogen concentrate, the other received cryoprecipitate (a blood product). The goal was to see if the concentrate works as well as cryoprecipitate to reduce the need for blood transfusions. The trial included 31 children and will help plan a larger study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fibrinogen concentrate (Fibryga) and cryoprecipitate
What this could lead to: If it works, this could offer a safer, more standardized option to control bleeding in young children after heart surgery.
What could go wrong: This is a small pilot study with only 31 children, so results may not apply to all patients. The trial is not designed to prove superiority, only to guide a larger study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hemorrhage hemorrhagic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLEEDING PEDIATRIC HD

Contacts and locations

Locations

University of Virginia Health System

Charlottesville, Virginia, 22908, United States

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