AML

This early-stage study tests the safety of a new drug called ziftomenib when combined with standard chemotherapy for people whose acute myeloid leukemia (AML) has returned or not responded to treatment. The study includes adults with specific genetic changes (NPM1 mutation or KMT…

This early-phase trial tests a new drug called revumenib alongside standard chemotherapy and a targeted therapy (midostaurin) for adults with a specific genetic form of acute myeloid leukemia (AML). The goal is to find a safe dose that improves remission rates. About 22 newly dia…

This study tests whether giving special immune cells (memory-like NK cells) after a stem cell transplant can help control high-risk acute myeloid leukemia (AML) in children and adults. About 68 participants will receive donor stem cells followed by these NK cells. The goal is to …

This study tests whether giving two drugs (decitabine and filgrastim) after a stem cell transplant can safely prevent leukemia or related blood cancers from coming back in children and young adults. About 37 participants with acute myeloid leukemia, myelodysplastic syndromes, or …

This study is for people aged 14 to 60 with a specific genetic subtype of acute myeloid leukemia (AML) called RUNX1-RUNX1T1. It compares two different doses of a chemotherapy drug (cytarabine) given with another drug (anthracycline) to see which leads to longer survival. The goal…

This early-phase study tests a new treatment called CER-1236 for people with acute myeloid leukemia, myelodysplastic syndrome, or myelofibrosis that has not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recog…

This study tests a new way to prepare stem cells for transplant in children and adults with blood cancers like leukemia. The method removes certain immune cells to lower the risk of graft-versus-host disease, a serious side effect. About 70 participants will receive the treatment…

This study tests a stem cell transplant approach for people with blood cancers like AML and MDS. It uses milder chemotherapy (treosulfan and fludarabine) followed by a donor stem cell infusion, plus drugs to prevent graft-versus-host disease. The goal is to improve survival at 10…

This study tests a combination of three drugs—venetoclax, ivosidenib, and azacitidine—in adults with acute myeloid leukemia (AML) that has an IDH1 mutation. The goal is to see if this triple therapy can improve remission rates and survival. About 23 participants will receive the …

This study tests a three-drug combination (gilteritinib, venetoclax, and azacitidine) in 66 adults newly diagnosed with acute myeloid leukemia (AML) who have a specific genetic change called FLT3 mutation. The goal is to find the best dose and see how well the treatment controls …

This early-stage trial tests a combination of two drugs, CC-486 and venetoclax, in people with acute myeloid leukemia (AML) whose cancer has returned or not responded to treatment, as well as some newly diagnosed patients. The main goal is to find the safest dose of CC-486 when g…

This early-phase study tests whether specially engineered donor immune cells (TSC-100 or TSC-101) can safely reduce the risk of cancer returning in adults with acute myeloid leukemia, myelodysplastic syndromes, or acute lymphoblastic leukemia after a stem cell transplant. About 7…

This study tests a new automated method to select specific stem cells (CD34+) for patients with blood cancers who need a stem cell boost or second transplant. The goal is to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the pa…

This study compares two drug combinations to prevent graft-versus-host disease (GVHD) after a stem cell transplant in people aged 65 and older with acute myeloid leukemia or related blood cancers. Participants will receive either cyclophosphamide, sirolimus, and mycophenolate mof…

This study tests whether giving two common heart medicines (a beta blocker and an ACE inhibitor) before and during strong chemotherapy can prevent heart damage in people with newly diagnosed acute myeloid leukemia (AML). About 70 adults will be randomly assigned to receive the he…

This early-phase study tests a new drug called CG009301 in adults with blood cancers (like leukemia or MDS) that returned or didn't respond to standard treatments. The main goals are to find a safe dose and check for side effects. About 45 participants will receive the drug until…

This study tests a new drug called JAB-8263 in adults with advanced solid tumors (like lung or ovarian cancer) or blood cancers (like leukemia) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 15…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or non-cancerous blood disorders who do not have a matched family donor. The main goal is to see how many patients are alive without treatment-re…

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study follows about 1,000 people who previously received an experimental T-cell therapy (TSC-100 or TSC-101) for blood cancers like leukemia. Researchers will track participants for up to 15 years to see if any long-term side effects occur and how well they survive. The goal…

This study looks at whether a protein called leptin, found in bone marrow fluid, can help predict how well chemotherapy will work in adults with acute myeloid leukemia (AML). Researchers will measure leptin levels in 86 newly diagnosed patients before treatment and compare them t…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…