Vision disorder

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This early-stage trial tests whether adding the drug valproate to standard patching therapy can improve vision in children aged 8 to 17 with lazy eye (amblyopia). Participants will take valproate or a placebo daily for 8 weeks while patching the stronger eye. The study aims to se…

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This phase 3 trial tests an experimental drug called sepofarsen in 32 people with Leber congenital amaurosis (LCA), a rare genetic condition that causes severe vision loss from birth. The drug is injected into one eye, while the other eye gets a placebo, to see if it safely impro…

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests a new, noninvasive eye-tracking system that uses artificial intelligence to check vision in children, including babies and those with special needs who cannot do standard eye tests. Researchers will enroll 1,300 participants to see if the system can accurately de…

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study compares a technology-enhanced eye exam to a standard optometric exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults at a Federally Qualified Health Center will be randomly assigned to one of the two exa…

This phase 3 trial tests whether two different eye treatments can prevent vision loss in people who have had radiation therapy for a type of eye cancer called uveal melanoma. The study will compare faricimab injections given every 3 months, a fluocinolone acetonide implant placed…

Researchers are testing whether a multidisciplinary vision rehabilitation programme improves quality of life more than low vision training alone for adults with visual impairment. The trial enrolls 1,000 Cantonese-speaking adults in Hong Kong aged 18 to 80 who have a clinical dia…

This study tests whether phentolamine eye drops can improve vision in low light for people who had laser eye surgery and now see glare, halos, or starbursts at night. About 200 adults will use the drops or a placebo every evening for two weeks. The main goal is to see if more peo…

This study looks at whether special posture exercises or a wearable sensor can help improve mild vision problems in university students with forward head posture. 72 participants will be split into three groups to compare different training methods. The goal is to see if correcti…

This program provides comprehensive low vision rehabilitation services to children aged 3 to 21 with vision impairment. Participants are prescribed optical devices and trained to use them, with the goal of improving their visual functioning and ability to read. The program aims t…

This study tests whether 5 weekly sessions of eye exercises with real-time visual and audio feedback can improve how people with central vision loss use their peripheral vision. About 12 participants with bilateral central vision loss from macular degeneration will do saccadic an…

This pilot study tests whether a non-invasive headset that delivers mild electrical stimulation to nerves behind the ear can safely improve sleep in adults who are blind or severely sight impaired. Sixty participants will use the device for 30 minutes a day, five times a week for…

This study tests whether a simple PowerPoint program that shows moving images in the blind part of a person's vision can help expand their visual field. The trial enrolls 40 adults with hemianopsia (partial blindness) after stroke or brain injury. Participants will watch slides w…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study is testing a multi-sensory rehabilitation program for people with ultra low vision (visual acuity of 20/1600 or worse). The program includes training to use remaining vision better and to combine input from different senses. Researchers hope this will improve daily fun…

This study tests a wearable device that uses directional sound to help people with low vision detect obstacles. Fifty participants with normal vision will wear a blindfold and walk a path with obstacles, once with the device and once without. The device emits tones that get loude…

This study compares telerehabilitation (remote training) to in-office care for adults with low vision who have received new magnification devices or assistive apps. Researchers will also use Bluetooth sensors to monitor if patients stop using their devices, aiming to provide time…

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study investigates whether performing the same visual search task repeatedly changes how people search compared to when tasks are mixed. Healthy adults will complete four search tasks, either in blocks or randomly intermixed, while response times and accuracy are measured. T…

This study explores whether giving people a choice in the sequence of visual search tasks changes how they perform. Participants will complete four search tasks where the target stays the same but distractors vary, either in blocks or intermixed, with some degree of choice. The g…

This study tests a smartphone-based tool called VisionWay that helps people with visual impairments choose the most accessible walking path before they start walking. Researchers will ask participants to walk different routes on a university campus and rate sidewalk features like…

This study is following 5,000 adults aged 65 and older to learn how eye diseases develop and progress over time. Researchers will collect detailed health information, eye exams, and biological samples to build a comprehensive database. The goal is to create a personalized risk pr…

This study looks at how healthy adults judge distances and heights of objects while walking. Participants will estimate where things are before and after moving. The goal is to learn more about how our brains process space during motion, which could help understand vision problem…

This study looks at whether the pattern of contrast on stair edges helps older adults, including those with low vision, step more safely. Participants walk on lab stairs with different contrast markings while their foot clearance is measured. The goal is to understand how contras…

This study looks at whether a balance exercise called IVA is safe and helpful for adults who have vision problems, with or without inner-ear balance issues. Researchers will compare two groups: people with vision problems only and those with both vision and inner-ear problems. Pa…

This study looks at how blind people use a white cane to sense the world around them, not just to move. Researchers will test how well users can feel where a touch happens on the cane and measure brain activity during these tasks. The goal is to understand how the cane becomes an…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study looks at how seeing one skin image after another can influence a doctor's judgment, potentially causing errors. Researchers will test over 10,000 people, including doctors and untrained volunteers, to measure these biases. The goal is to find ways to reduce mistakes in…

This study is testing whether a special training program can help children with visual impairment learn better viewing strategies. The training involves six weeks of exercises that teach kids how to look in a structured way, zoom in and out, and tell objects apart. Researchers wi…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study looks at how color vision changes over time in people with inherited retinal diseases (IRDs). Researchers will study 200 participants, including those with IRDs and healthy volunteers, to see how color vision loss relates to changes in the retina's structure. They are …

This study is testing a new virtual reality (VR) test called VisionumVR to see if it can reliably measure how well people with low vision improve during rehabilitation. About 60 participants who are starting or already in orthoptic low vision therapy will take a 20-minute VR task…

This study is for people with diabetic macular edema, a condition that causes vision loss. Researchers want to see if certain substances in the blood and patterns on eye scans can predict how well a patient will respond to two common treatments: anti-VEGF injections or a dexameth…

This study looks at how older adults with and without vision problems step over obstacles of different heights and colors. Researchers want to understand how vision and eye movements affect walking to help prevent falls. About 200 adults who can walk on their own will take part.