Urinary bladder neoplasm

This study tests whether adding an experimental treatment (V940) to standard BCG therapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning. About 308 adults will be randomly assigned to get either V940 plus BCG or BCG alone.…

This study tests a new drug called MK-3120 for high-risk non-muscle invasive bladder cancer. After standard tumor removal, 45 participants will receive the drug directly into the bladder. The main goals are to check safety and how well people tolerate it, while also looking at tu…

This study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will receive either the drug combo or standard chemoradiatio…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This study tests whether adding a new targeted medicine (vepugratinib) to two standard cancer drugs can help people with advanced bladder cancer that has a specific genetic change (FGFR3). About 450 adults whose cancer has spread or cannot be removed by surgery will take part. Th…

This early-stage trial is testing a new oral drug called LOXO-435, alone or with other cancer medicines, in people with advanced solid tumors that have a specific change in the FGFR3 gene. The study aims to find the right dose and check for safety and early signs of effectiveness…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder cancer surgery is safe and effective. About 150 people with muscle-invasive bladder cancer will receive durvalumab plus either ddMVAC or gemcitabine/cisplatin chemo…

This early-stage trial is testing a new drug called sigvotatug vedotin, alone or with other cancer medicines, in people with advanced solid tumors like lung, head and neck, and breast cancers. The study aims to find a safe dose and check for side effects. About 1,000 participants…

This expanded access program provides vepugratinib, an oral drug, to people with metastatic urothelial carcinoma or other solid tumors that have a specific FGFR3 genetic change. Participants must have exhausted other approved treatments, including erdafitinib for bladder cancer, …

This study tests a new drug that delivers radiation directly to cancer cells carrying a protein called DLL3, found in small cell lung cancer and other solid tumors. The trial enrolls 138 adults whose cancer has progressed after at least two prior treatments. The goal is to check …

This study compares 3 versus 6 cycles of platinum-based chemotherapy followed by the immunotherapy drug avelumab in 320 people with advanced bladder cancer. The goal is to see if fewer chemo cycles improve quality of life without harming cancer control. Participants receive eithe…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

Researchers are testing whether MRI scans can accurately show whether bladder tumors have grown into the muscle wall, a key factor in choosing treatment. The trial enrolls 150 adults with bladder tumors who are scheduled for a transurethral resection (TURB), a surgical biopsy. Do…

This study compares three imaging methods—FAPI PET/MRI, FDG PET/MRI, and MRI—to see which best detects muscle-invasive bladder cancer and tracks how well pre-surgery treatment works. Researchers will enroll 80 participants with suspected or confirmed bladder cancer. The goal is t…

This early-phase study tests a new MRI technique that uses two contrast agents (gadobutrol and ferumoxytol) placed directly into the bladder to improve staging of bladder cancer. Researchers will compare MRI images to actual tumor samples from surgery to see if the scan can accur…

This study is looking at whether analyzing DNA and proteins in urine can help detect cancers of the bladder and kidney without invasive procedures. Researchers will collect urine samples from 500 adults, including those with known or suspected cancer and healthy volunteers. The g…

This study tests whether a simple breathing exercise called the 4-7-8 technique can help people sleep better, feel less pain, and recover faster after bladder surgery. About 68 adults having this surgery will be randomly assigned to either learn the breathing exercise or receive …

This study looks at 56 adults with non-muscle-invasive bladder cancer who receive BCG therapy, a standard treatment that often causes painful bladder symptoms. Researchers want to see if giving Blad-Care (a gel that restores the bladder's protective lining) early during BCG treat…

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study looks back at medical records of 250 people in Portugal diagnosed with high-risk non-muscle-invasive bladder cancer between 2016 and 2020. The goal is to see how these patients are actually diagnosed, treated, and followed in everyday practice—including which surgeries…

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…