Severe cutaneous adverse reaction

This Phase 2 trial tests whether small interfering RNA (siRNA) microneedle patches can improve the appearance of earlobe keloid scars after laser surgery. About 158 adults with earlobe keloids will receive either standard steroid injections alone or steroid injections plus the si…

This Phase 2 trial tests whether adding benralizumab (a drug already used for asthma) to standard corticosteroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, severe allergic reaction to certain medications tha…

This study tests whether a genetic test can prevent rare but severe skin reactions caused by the common gout drug allopurinol. About 228 Vietnamese adults with gout will either get the test before treatment or receive standard care. Those with a high-risk gene will take a differe…

This study tests whether a topical eye drop called timolol can help surgical wounds on the scalp heal faster and look better after Mohs surgery. About 40 adults will either use timolol or standard wound care. Researchers will check healing and scar appearance at 4, 8, and 12 week…

This phase 2 trial tests whether verteporfin, a drug injected into the skin during tummy tuck surgery, can reduce scar formation. Twelve adults will receive different doses of verteporfin and a placebo in separate parts of their surgical wound. Researchers will compare scar appea…

This study will test the safety of a new biologic drug called stapokibart, given as a shot, in 400 adults with seasonal allergic rhinitis (SAR). Participants are already prescribed the drug by their doctor. The main goal is to track any side effects. This is an open-label study, …

This study tests whether a procedure called dermabrasion, which sands the skin, can improve the appearance of scars from free flap reconstruction in the head and neck. Forty adults who had flap surgery at least three months ago will have half their scar treated and half left alon…

This study compares a modern silver foam dressing to a traditional dry silver dressing for chronic wound infections. Researchers will track how much the wound shrinks in two weeks and how many wounds fully heal. The goal is to find which dressing works better and costs less for p…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …