Severe cutaneous adverse reaction

This trial tests an engineered skin graft called denovoSkin™, made from a patient's own skin cells, for treating deep burns. It aims to see if this graft can close wounds and reduce scarring better than the standard split-thickness skin graft. The study includes adults and adoles…

This study tests whether injections of stem cells from donated fat tissue can improve the quality of old burn scars. 39 adults with hypertrophic scars (at least 2 years old) will receive stem cells in one scar area and a placebo in another. The main goal is to see if patients rep…

This trial tests whether radiofrequency ablation (RFA) can safely and effectively treat superficial lipomas—benign fatty lumps under the skin—without leaving a scar. Instead of cutting out the lipoma, a thin needle delivers heat to melt it, guided by ultrasound. The study will me…

This study compares two types of stitches (dissolvable fast gut and non-dissolvable polypropylene) to see which leads to less scarring and pigment changes in people with darker skin. Each participant's wound is split in half, with one stitch type on each side, and scarring is mea…

This study tests whether a special laser can make burn scars look and feel better. Researchers will treat mature burn scars on the body and measure changes in scar height, texture, color, and flexibility. The study involves 6 adults in Winnipeg with scars that are 6-12 months old…

This study looks at whether pulsed dye laser therapy can make burn scars less red, softer, flatter, and more flexible. Researchers will treat people with burn scars that are 1 to 6 months old and living in Winnipeg. The goal is to see if the laser helps scars heal better.

This study tests a new drug called 9MW3811 for people with thick, raised scars that haven't improved in 6 months. About 30 adults will receive either the drug or a placebo to see if it makes scars look and feel better. The goal is to reduce scar thickness, color, pain, and itchin…

This study tests whether microneedling or dermabrasion works better for improving the look of early surgical scars on the face. Thirty adults with a vertical scar on the upper forehead will receive one of the two treatments. Researchers will measure scar appearance using standard…

This study tests a cream containing FS2 (kynurenic acid) to see if it can reduce scarring in burn patients who need skin grafts. About 70 people aged 12 to 65 will apply the cream or a placebo to both the graft and donor sites for 90 days. The goal is to check safety and whether …

This study looks at two ways to close the surgical cut after gynecologic cancer surgery: using staples or separate stitches versus a continuous stitch under the skin. The goal is to see which method helps women feel better about their body image and mood. About 140 women will ans…

This study tests whether adding a special gauze dressing (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Sixty adults will have their wound closed normally, then half the wound gets the extra bolster. Doctors and patie…

This study looks at children with congenital melanocytic nevi (large birthmarks) who choose to have them surgically removed. Researchers want to see if removal improves quality of life and reduces feelings of being stigmatized. About 100 children aged 9 months to 16 years will be…

This study tests two different ways to close skin wounds after surgery: one stitch placed under the skin and one through the skin. About 73 adults having skin procedures on their head, neck, trunk, or limbs will have half their wound closed with each method. After three months, d…

This study tests a new injectable filler made from hyaluronic acid and collagen to improve wrinkles, scars, and skin looseness on the face. Forty non-smoking adults aged 18-70 will receive one treatment and be followed for 16 weeks. Researchers will check for side effects and mea…

This study tests whether a locking stitch or a standard stitch reduces scarring better after surgery on the head or neck. Fifty adults will have their surgical wound split in half, with each side closed using a different method. Blinded reviewers and patients will rate the scars …

After Mohs surgery on the scalp, wounds are often left to heal on their own, which can take 8 weeks or more. This study tests whether a pinch graft—a thin piece of skin taken from the groin and placed in the wound—can help the wound heal faster. Researchers will compare healing t…

This study aims to understand how a type of white blood cell called eosinophils contributes to DRESS syndrome, a severe and potentially life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunte…

This study aims to find the genes that cause or contribute to keloid scarring. Researchers will analyze DNA from 7,000 people who have keloids, as well as their unaffected family members. The goal is to better understand why some people develop these raised scars, which could lea…

This study looks at how abnormal blood vessel growth (angiogenesis) contributes to various skin diseases like rosacea, psoriasis, and certain tumors. Researchers will collect skin samples from 85 volunteers aged 16 and older to analyze markers of angiogenesis. The goal is to bett…