Severe cutaneous adverse reaction

This study compares two treatments—nanofat injections and fractional CO2 laser—used alone or together for post-traumatic atrophic scars (depressed scars from injury). Sixty participants receive one of the three approaches. The goal is to see if combining both treatments improves …

This study tests a new lab-grown skin substitute (EHSG-KF) for treating deep burns in adults and teens. It compares the substitute to standard skin grafts to see if it covers wounds better and is safer. The goal is to improve healing and reduce the need for large skin donations f…

This study tests whether combining two types of laser treatments—pulsed dye laser (PDL) and fractional photothermolysis—can improve how surgical scars look. Adults who had a dermatologic surgery on their trunk or limbs can join. Some participants receive the laser combination at …

This study compares two devices—ePrime (radiofrequency) and Fraxel (laser)—to see which improves acne scars more. Each participant gets both treatments on different sides of their face, and a blinded dermatologist rates the results. The goal is to find a more effective way to red…

This study tests whether lightly sanding the skin edges during Mohs surgery (a type of skin cancer removal) can improve how scars look after healing. Thirty adults having facial or neck surgery will have half their scar treated with dermabrasion and the other half left as standar…

This study tests whether a special silicone dressing (Neodyne embrace) can improve the appearance of abdominal scars in women who had breast reconstruction using tissue from their belly. Thirty women will have part of their incision treated with the dressing and the other part le…

This study looks at whether applying a silicone ointment to the skin before head and neck surgery helps wounds heal with less scarring. About 60 adults having non-emergency surgery will take part. Researchers will compare scars using standard rating scales and also track hospital…

This study looks at a way to possibly reduce scarring after surgery on the neck, trunk, arms, or legs. The technique, called "undermining," involves loosening the skin near the wound tips to reduce tension. Half of each wound will get this extra step, and the other half will not,…

This study tests whether injecting botulinum toxin (Botox) into biopsy wounds can reduce scarring compared to a placebo. Twelve healthy adults will each receive both treatments on different spots on their back, and scars will be compared over six months. The goal is to see if Bot…

This study planned to test a fractional ablative erbium laser on scarring caused by hidradenitis suppurativa (HS) in the armpit area. It was designed for adults with mild HS activity and visible scars. However, the trial was withdrawn before enrolling any participants, so no resu…

This study looks at how skin elasticity differs by age and skin type, both on normal facial skin and on surgical scars. Researchers will compare people who have had a skin resurfacing or tightening procedure with those who have not. The goal is to create baseline elasticity score…

This study looks at whether using sunscreen on a healing surgical scar improves how it looks. Fifty adults who had skin cancer surgery will have half of their scar treated with sunscreen and the other half left alone. After three months, doctors will compare the two sides to see …

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…

This study looks at whether artificial intelligence (AI) can match a dermatologist's diagnosis when a general practitioner sends in photos and questions about a patient's skin condition. Researchers will compare the AI's diagnosis to the dermatologist's for about 1000 adults. The…