Severe acute respiratory syndrome

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This Phase 2 trial tested the BNT162b2 mRNA vaccine in 960 healthy Chinese adults aged 18 to 85. Participants received two doses of either the vaccine or a placebo, 21 days apart. The main goal was to check safety and measure the immune response, specifically neutralizing antibod…

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested two drugs—remdesivir and aviptadil—in hospitalized COVID-19 patients with severe breathing failure. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if these drugs could safely improve ou…

This completed Phase 3 trial tested the safety and effectiveness of remdesivir in 87 hospitalized COVID-19 patients with acute respiratory distress syndrome (severe breathing failure). Participants received either remdesivir plus standard care or a placebo plus standard care for …

This phase 3 trial tested whether the drug aviptadil can help hospitalized COVID-19 patients with acute respiratory distress syndrome (ARDS). 471 participants received either aviptadil plus standard care or a placebo plus standard care. The main goal was to see how well patients …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This completed study looked at over 131,000 high-risk COVID-19 patients in the US to understand how the illness affected their ability to work and the associated costs. Researchers compared those who took the antiviral Paxlovid with those who did not, using insurance claims data …

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at why some COVID-19 patients lose their sense of smell. Researchers compared nasal cell samples from 26 people—some with COVID-19 and smell loss, and some healthy controls. They aimed to find molecular and cellular differences in the nose that might explain the…