Sebaceous gland disorder

This study tests an mRNA vaccine designed to fight acne. Researchers will give two shots to 120 adults aged 18 to 45 with mild acne. The goal is to see if the vaccine is safe and reduces pimples. Participants are randomly assigned to receive the vaccine or a placebo.

This study compares giving oral isotretinoin (a strong acne medication) right away versus the usual antibiotics for moderate acne in people with darker skin (Fitzpatrick types IV-VI). The goal is to see if early use of isotretinoin reduces acne-related dark spots better than stan…

This study compares a weekly dose of isotretinoin (a vitamin A derivative) to daily tetracycline antibiotics for treating moderate acne. Researchers want to see if the weekly approach works just as well, with fewer side effects and less reliance on antibiotics. The trial will enr…

This study tests an experimental mRNA vaccine designed to treat moderate to severe acne in adults aged 18 to 45. The vaccine is given as up to three injections into the muscle. Researchers will monitor safety, immune response, and how well it reduces acne lesions. The trial invol…

This study tests a cream made from a common probiotic, Lactobacillus reuteri, that has been coated with a special material to help it survive on the skin. The goal is to see if it can rebalance the skin's bacteria and reduce acne. About 196 people with mild to moderate acne will …

This study tests whether cold atmospheric plasma (CAP) can safely and effectively treat moderate-to-severe acne. 220 adults aged 18-40 will receive either CAP or a placebo treatment once a week for six weeks. The goal is to see if CAP reduces acne lesions better than placebo, off…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This early-stage trial tests an experimental oral drug called TVB-3567 in 128 healthy adults, some with acne. The main goal is to check safety and how the body processes the drug, not yet whether it works. Results will help decide if larger studies are warranted.

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests if timolol eye drops, applied as a cream, can reduce the red marks left after acne. It compares the drops to intense pulsed light (IPL) therapy in 60 people aged 12 and older. The goal is to see if a simple, low-cost option can work as well as a laser treatment.

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests a cream called trifarotene on Chinese people aged 9 and older with moderate acne on the face and upper body. About 561 participants will apply the cream or a placebo daily for 12 weeks. The goal is to see if the cream reduces acne lesions and improves skin appear…

This study looks at whether isotretinoin, a common acne medicine, changes how well people can smell. Researchers will test the sense of smell in 54 adults before and after at least 4 weeks of treatment. The goal is to understand if the drug's drying effect on the nose can reduce …

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study looks at how two common acne antibiotics, sarecycline and doxycycline, change the bacteria living in your gut and on your skin. Researchers will track these changes in 30 people with acne over the treatment period. The goal is to understand which antibiotic is gentler …

This study is creating a group of 200 acne patients at Nantes University Hospital to learn more about the disease. Researchers will track factors like acne severity, quality of life, and treatment costs, and collect skin samples. The goal is to better understand what makes acne w…

This study collects skin samples from 500 people with conditions like acne, eczema, and psoriasis, as well as healthy volunteers. Researchers will analyze the samples to find biomarkers and gene patterns linked to inflammation. The goal is to better understand these skin diseases…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…