Pouchitis

This study tests an experimental drug called CLF065 in 20 adults with chronic pouchitis, a condition causing inflammation in a surgically created internal pouch. Participants receive weekly doses of CLF065 or a placebo to see if the drug safely reduces symptoms and inflammation. …

This study tests whether the drug guselkumab (Tremfya), with or without a low-processed-food diet, can help people with chronic pouchitis—a painful gut condition that can occur after surgery for ulcerative colitis. Twenty adults who have not responded to antibiotics will receive …

This study tests whether mirikizumab (Omvoh) can reduce symptoms of chronic pouchitis, a condition where the internal pouch created after colon surgery becomes inflamed. Twenty-five adults will receive the drug every four weeks for a year. Researchers will track symptom changes u…

This study tests whether vedolizumab (Entyvio) can improve symptoms and reduce inflammation in children with chronic pouchitis, a condition where an internal pouch becomes inflamed after bowel surgery. About 30 children will receive up to 12 infusions over 82 weeks. The main goal…

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This study tests whether the drug etrasimod can prevent pouchitis, a common inflammation of the internal pouch created after colon removal surgery. Researchers will give either etrasimod or a placebo to 40 high-risk patients for 48 weeks and track how many develop pouchitis. The …

This study tests a new treatment called EXE-346, which is a mix of 8 types of good bacteria. It aims to reduce how often people with an ileal pouch (a surgically created internal reservoir) need to have bowel movements. The trial will enroll 50 adults and first check safety, then…

This study compares using one doctor versus two doctors to perform a procedure called single-balloon enteroscopy, which looks deep into the small intestine. About 228 adults with suspected small bowel disease will be randomly assigned to either technique. The goal is to see if on…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study tests whether using a predictive model before a double-balloon enteroscopy helps doctors fully examine the small intestine. About 338 adults with suspected small-bowel disease will be randomly assigned to have their doctor see the model score or not. The main goal is t…