Can a stool transplant soothe an inflamed pouch?

NCT ID NCT05829109

NEW Recruiting now Disease control Sponsor: Maia Kayal Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial tests whether fecal microbiota transplant (FMT) — transferring stool from a healthy donor pouch into an inflamed one — can safely ease chronic pouchitis, a complication after ulcerative colitis surgery. Participants first take antibiotics and a bowel prep, then receive two FMT enemas a week apart. The study tracks safety and whether patients achieve clinical remission and endoscopic improvement by week 8.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal microbiota transplant (FMT) via enema, preceded by antibiotics and bowel prep
What this could lead to: If successful, this could offer a new way to treat chronic pouchitis by restoring a healthy gut microbiome, potentially reducing the need for long-term antibiotics.
What could go wrong: This is a very early, small trial (16 people), so results may not apply broadly. Risks include infection or reactions from the transplant, and the procedure may not work.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHRONIC POUCHITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

pouchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC POUCHITIS POUCHITIS

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.