Could friendly bacteria help pouch patients poop less?

NCT ID NCT05938465

Recruiting now Symptom relief Sponsor: Exegi Pharma, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new treatment called EXE-346, which is a mix of 8 types of good bacteria. It aims to reduce how often people with an ileal pouch (a surgically created internal reservoir) need to have bowel movements. The trial will enroll 50 adults and first check safety, then see if it actually cuts down on bathroom trips. If successful, it could improve daily life for those with this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EXE-346 (a blend of 8 strains of lactic acid bacteria)
What this could lead to: If it works, this could offer a new way to reduce frequent bowel movements and improve quality of life for people with an ileal pouch.
What could go wrong: This is an early-phase trial with only 50 participants, so results may not apply to everyone. The treatment is a live bacteria product, which carries unknown risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pouchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ILEAL POUCH

Contacts and locations

Locations

Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Mayo Clinic - Florida (Inflammatory Bowel Disease Center)
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Department of Gastroenterology
RECRUITING

Rochester, Minnesota, 55905, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Penn State Health (Milton S. Hershey Medical Center)
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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