Pouchitis
MONDO:0005312Acute inflammation in the intestinal mucosa of the continent ileal reservoir (or pouch) in patients who have undergone ileostomy and restorative proctocolectomy (proctocolectomy, restorative).
22 clinical trials for this condition and its sub-types.
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New hope for pouchitis sufferers: experimental drug enters trial
Disease control TerminatedThis study tests an experimental drug called CLF065 in 20 adults with chronic pouchitis, a condition causing inflammation in a surgically created internal pouch. Participants receive weekly doses of CLF065 or a placebo to see if the drug safely reduces symptoms and inflammation. …
Phase: PHASE2 • Sponsor: Calibr, a division of Scripps Research • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Stem cell shot for pouchitis fails to launch
Disease control TerminatedThis study aimed to test whether injecting stem cells from a donor's bone marrow into the pouch (a surgically created internal reservoir) could safely treat pouchitis that hadn't improved with antibiotics or other drugs. The trial was planned for 12 adults aged 18-75 in the U.S.,…
Phase: PHASE1 • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Poop pills may stop gut Flare-Ups after colitis surgery
Disease control OngoingThis study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent pouchitis, a common complication after ulcerative colitis patients have their colon removed and a pouch created. About 42 adults who have had this surgery and have had pouchitis…
Phase: PHASE3 • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC