Post-COVID-19 disorder

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study looks at a blood-filtering procedure called immunoadsorption (IA) in 50 people with ME/CFS or Post-COVID syndrome who have certain autoantibodies. The goal is to see if removing these antibodies improves symptoms like severe fatigue and brain fog. Researchers will trac…

This expanded access program offers REGENECYTE, a human umbilical cord blood infusion, to adults with Long COVID who cannot join other clinical trials. Participants must have a recent negative COVID-19 test and provide consent. The goal is to provide potential treatment access wh…

This phase 2 trial tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID who also have POTS (a condition causing rapid heart rate upon standing). The study will enroll 50 participants and randomly assign them to receive either 2-HOBA o…

Some people with long COVID have harmful antibodies that may be attacking their own bodies, causing severe fatigue and other symptoms. This study tests a treatment called immunoadsorption, which filters the blood to remove those antibodies. About 70 participants will receive eith…

This study tests a supervised online program called SuperCAP to see if it can improve thinking and daily functioning in people with long COVID. One hundred adults with post-COVID cognitive difficulties will either use the program or receive standard education. The goal is to redu…

This trial tests whether a type of magnetic brain stimulation, called transcranial magnetic stimulation (TMS), can improve symptoms of post-COVID syndrome, such as loss of smell, ringing in the ears, and fatigue. About 40 people who have had these symptoms for over a month after …

This phase II trial tests whether the drug sonlicromanol can reduce fatigue in 80 people with long COVID who experience post-exertional malaise (worsening symptoms after activity). Participants take the drug or a placebo twice daily for 13 weeks, and researchers measure changes i…

This trial tests whether a program built around small, deliberate choices — called micro-choices — can help people with persistent fatigue, including those with long COVID. Participants attend a four-day group workshop and receive three weeks of digital support to build new habit…

This study tests whether fluvoxamine, an antidepressant, can reduce severe fatigue and other symptoms in people with post-COVID. 160 adults aged 18-70 with long-lasting fatigue after COVID will receive either the drug or a placebo for 12 weeks. The goal is to see if it improves e…

This study tests if a nerve block injection in the neck can reduce long-COVID symptoms like fatigue, brain fog, and heart palpitations. About 78 adults with post-COVID condition will get either the real block or a fake injection to see if it helps. The goal is to find a safe, eff…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be ra…

This study tests a small device that sends gentle electrical pulses to nerves in the ear to help children ages 11-18 with post-concussion syndrome or long COVID symptoms like pain, nausea, and balance problems. Participants must have had symptoms for at least 3 months. The goal i…

This study tests if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can ease lingering symptoms like brain fog and fatigue in people with Long COVID. Researchers will enroll 120 adults who had COVID-19 at least 3 months ago. The goal is to see if this t…

This study tests whether a 12-week exercise program delivered through a smartphone app can improve physical function and heart health in people with long COVID. Sixty adults with ongoing fatigue or shortness of breath after a COVID-19 infection will be randomly assigned to either…

This study looks at whether special breathing exercises combined with core-strengthening moves can help people with Post-COVID syndrome. About 40 adults aged 18-65 will do either core exercises alone or core plus breathing training for 8 weeks. Researchers will measure changes in…

This study tests whether a device that sends gentle sound pulses to the brain can reduce fatigue, brain fog, and mood problems in people with long COVID. 102 adults who have had COVID-19 at least 12 months ago will receive either real or fake (sham) treatment over five sessions. …

This study tests a gentle brain stimulation technique called rTMS to see if it can reduce severe fatigue and concentration problems in people with long COVID. Researchers will give 66 adults either real or fake (placebo) stimulation over six weeks. The goal is to find a safe, non…

This study tests if cold water therapy (Kneipp hydrotherapy) can improve quality of life for people with Long COVID. Thirty adults with a Post-COVID diagnosis will either receive the cold water treatment or continue usual care. Researchers will measure changes in fatigue, sleep, …

This study tests whether a home-based, supervised group exercise program can help high-risk Veterans recover their fitness after COVID-19. 80 Veterans with conditions like high blood pressure or diabetes will do guided workouts from home. The goal is to improve heart and lung fun…

This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different tre…

This study gives a single dose of kisspeptin, a natural hormone, to 40 people with and without Long COVID. Researchers will take frequent blood samples to measure how the brain's reproductive hormone system responds. The goal is to understand if Long COVID disrupts this system, w…

This study looks for specific signs of long COVID in the brain and blood. Researchers will compare people with and without long COVID symptoms using brain scans and blood tests. The goal is to find objective markers that could help doctors diagnose long COVID more reliably.

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study looks at how different sleep-wake patterns (called circadian rhythms) affect breathing strength, physical activity, and eating habits in people with Post-COVID syndrome. Researchers will study 50 adults aged 18-65 who have been diagnosed with long COVID. The goal is to…

This study follows 650 adults in Quebec to learn about the short- and long-term health problems caused by COVID-19, including damage to the heart, lungs, kidneys, and other organs. Participants include people who had mild, moderate, or severe COVID-19, as well as those who never …

This observational study will enroll 200 people in Navarre who have had COVID-19 and still have symptoms lasting more than 3 months. Researchers will collect information on demographics, health history, and ongoing symptoms to better understand long COVID. The goal is to describe…

This study focuses on people with ME/CFS or Long COVID who are too sick to leave home. Researchers will provide monthly in-home medical visits and create personalized care plans. The goal is to see if this approach improves patients' health and eases the burden on their caregiver…

This pilot study tests whether an intensified schedule of repetitive transcranial magnetic stimulation (iTBS) — six sessions a day for five days — works better than the standard one-session-a-day for six weeks in people with depression and Post-COVID condition. Researchers will m…