Peptic ulcer disease

This study tests a drug called esomeprazole, given through an IV, to prevent stress ulcers and acid reflux in 50 adults recovering from surgery in the intensive care unit (ICU). The goal is to see if it can keep stomach acid low enough to reduce the risk of bleeding. Participants…

This trial tests whether a newer acid-reducing drug, vonoprazan, is better than a double dose of the standard drug esomeprazole at preventing rebleeding in people who have had a bleeding stomach or intestinal ulcer treated with endoscopy. About 108 adults at high risk of rebleedi…

This phase 3 trial tests whether an experimental drug called DWP14012 (fexuprazan) can heal stomach ulcers as well as or better than the standard treatment lansoprazole. About 384 adults with at least one active gastric ulcer will receive either DWP14012 or lansoprazole daily for…

This trial tests whether an experimental drug called JP-1366 can prevent the return of erosive esophagitis in people whose condition has already healed. About 384 adults aged 19 to 75 will take either JP-1366 or the standard drug lansoprazole daily for 24 weeks. The goal is to se…

This study tests whether a digital bottle cap called FORTISKAP™ can detect missed doses of proton pump inhibitors (PPIs) in people with GERD more accurately than standard methods like pharmacy fill records or patient questionnaires. Fifty adults with GERD who take a daily PPI wil…

This study tests whether a simpler two-drug treatment (vonoprazan plus one antibiotic) works as well as a three-drug treatment (vonoprazan plus two antibiotics) for H. pylori infection. About 150 adults with confirmed H. pylori will take either regimen for 14 days. The main goal …

This study looks at whether adding sucralfate (a protective coating agent) to standard esomeprazole (a stomach acid reducer) helps heal artificial ulcers created during endoscopic surgery for early stomach cancer or precancerous growths. About 120 adults will be randomly assigned…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This study looks at whether the drug Fexuclue can prevent stomach ulcers in people who need to take NSAID pain relievers long-term. About 7,000 adults in Korea will take Fexuclue and report their stomach symptoms over 4 weeks. The goal is to see if the drug reduces ulcer symptoms…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study looks back at medical records from high-volume hospitals in Russia and China to compare how patients with stomach cancer or cancer at the junction of the stomach and esophagus fare after a specific surgery called proximal gastrectomy with double-tract reconstruction. R…

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study looks at whether combining a blood test for H. pylori bacteria with a painless stomach ultrasound can predict serious complications from peptic ulcers, like bleeding or a hole in the stomach. Researchers will study 230 adults with stomach symptoms to see if these non-i…

This study looks at whether using a device that helps see veins under the skin can make placing an IV in children faster and with fewer needle sticks. About 500 children under 18 who need an IV for day surgery or other procedures will take part. Researchers will compare the time …

Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it. Even so, published studies consistently report that…