Osteogenesis imperfecta
MONDO:0019019Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.
Also known as: Lobstein disease, OI, Osteopsathyrosis, Porak and Durante disease, brittle bone disease, glass bone disease, Vrolik disease
329 clinical trials for this condition and its sub-types, 35 tagged with Osteogenesis imperfecta itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Osteogenesis imperfecta
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Osteogenesis imperfecta and a reduction of bone mineral density. 0 trials · 307 incl. sub-types
34 sub-types
- Osteoporosis 277 trials · 295 incl. sub-types Sub-types →
- Osteogenesis imperfecta type 3 9 trials
- Osteogenesis imperfecta type 1 8 trials Sub-types →
- Osteogenesis imperfecta type 4 7 trials
- Osteogenesis imperfecta type 5 1 trial
- Bruck syndrome 2 0 trials
- Cole-Carpenter syndrome 1 0 trials
- Cole-Carpenter syndrome 2 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type, 1 0 trials
- Singleton-Merten syndrome 1 0 trials
- Singleton-Merten syndrome 2 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Autosomal recessive cutis laxa type 2A 0 trials Sub-types →
- Autosomal recessive cutis laxa type 2B 0 trials
- Calvarial doughnut lesions-bone fragility syndrome 0 trials
- Geroderma osteodysplastica 0 trials
- Gnathodiaphyseal dysplasia 0 trials
- Osteogenesis imperfecta type 10 0 trials
- Osteogenesis imperfecta type 11 0 trials
- Osteogenesis imperfecta type 12 0 trials
- Osteogenesis imperfecta type 14 0 trials
- Osteogenesis imperfecta type 15 0 trials
- Osteogenesis imperfecta type 16 0 trials
- Osteogenesis imperfecta type 17 0 trials
- Osteogenesis imperfecta type 2 0 trials
- Osteogenesis imperfecta type 6 0 trials
- Osteogenesis imperfecta type 7 0 trials
- Osteogenesis imperfecta type 8 0 trials
- Osteogenesis imperfecta type 9 0 trials
- Osteogenesis imperfecta, type 18 0 trials
- Osteogenesis imperfecta, type 19 0 trials
- Osteoporosis-pseudoglioma syndrome 0 trials
- Short stature-optic atrophy-Pelger-Huët anomaly syndrome 0 trials
- Spondylo-ocular syndrome 0 trials
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Brittle bone disorder 4 trials
1 sub-type
- Brittle bone syndrome lethal type 0 trials
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Osteogenesis imperfecta type 13 0 trials
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Osteogenesis imperfecta, IIA 22 0 trials
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Osteogenesis imperfecta, type 20 0 trials
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Osteogenesis imperfecta, type 21 0 trials
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Osteogenesis imperfecta, type 23 0 trials
Most studied deeper sub-types
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New drug aims to strengthen bones in kids with rare brittle bone disease
Disease control OngoingThis phase 3 study tests setrusumab, a monthly IV infusion, in 6 Japanese children with osteogenesis imperfecta (types I, III, or IV), a condition that causes fragile bones and frequent fractures. The main goal is to see if the drug lowers the number of fractures, including spine…
Phase 3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug aims to slash fractures in kids with brittle bones
Disease control OngoingThis study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab can reduce the number of …
Phase 3 • Sponsor: Amgen • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New drug aims to slash fractures in brittle bone disease
Disease control OngoingThis study tests a medicine called setrusumab in people with osteogenesis imperfecta (brittle bone disease). The goal is to see if it can lower the number of bone fractures. About 183 participants with types I, III, or IV of the disease who have had recent fractures will receive …
Phase 2/3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New drug aims to cut fractures in kids with brittle bones
Disease control OngoingThis study tests a new medicine called setrusumab against standard bone-strengthening drugs (bisphosphonates) in children aged 2 to under 7 with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if setrusumab can lower the number of bone break…
Phase 3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Fetal stem cells aim to mend broken bones in infants
Disease control OngoingThis early-phase trial tests whether fetal stem cells given before or after birth can safely help infants with severe osteogenesis imperfecta, a genetic condition causing fragile bones and frequent fractures. Up to 18 children will receive multiple doses of the cells. The main go…
Phase 1/2 • Sponsor: Karolinska Institutet • Aim: Disease control
Last updated Jun 26, 2026 15:45 UTC
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Invisalign offers hope for safer smiles in osteogenesis imperfecta
Symptom relief OngoingThis study tests whether Invisalign clear aligners can safely straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and dental work risky. About 57 participants aged 12 to 40 with mild to moderate teeth misalignment will receive treatm…
Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated Aug 20, 2026 00:00 UTC
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Breathing problems in brittle bone disease: new study seeks answers
Knowledge-focused OngoingThis study examines lung and heart function in 18 adults with osteogenesis imperfecta (OI), also known as brittle bone disease. Researchers want to understand why breathing problems are the leading cause of death in OI. Participants will undergo lung function tests and chest imag…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Brittle bone disease linked to severe teeth misalignment – new study investigates
Knowledge-focused OngoingThis study looks at teeth misalignment and neck defects in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans of the teeth, jaw, and neck to measure these problems in 75 participants aged 10 …
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Pee power: urine test may replace needles for brittle bone diagnosis
Knowledge-focused OngoingThis study is testing whether a urine test can help identify different genetic types of osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will measure certain collagen peptides in the urine of 25 people with OI. If successful, this coul…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC