Obstructive lung disease

This pilot study explores whether a newer ventilation method called flow-controlled ventilation (FCV) can help intubated patients with asthma or COPD exacerbations breathe with less effort compared to standard volume-controlled ventilation (VCV). Ten adult patients on mechanical …

This study tests a new way to give Alpha1-Proteinase Inhibitor—a medicine that helps protect the lungs in people with Alpha-1 Antitrypsin Deficiency. Instead of getting it through a vein at a clinic, participants will receive it as a weekly injection under the skin. The trial wil…

This study tests a special balloon coated with the drug paclitaxel to treat benign (non-cancerous) narrowing of the windpipe or main breathing tubes. The balloon is inflated to open the airway, and the drug may help keep it open longer. About 200 adults with this condition will b…

This study tests a short, scripted conversation between doctors and Black adults with uncontrolled asthma. The goal is to help patients and doctors make decisions together about asthma medicines. Researchers will enroll 400 adults at community health centers to see if this approa…

This study tests whether the drug vimseltinib is safe and effective for adults with moderate to severe chronic graft-versus-host disease (cGVHD) who have not improved after at least two prior treatments. About 48 participants will take vimseltinib daily for up to two years. The g…

This study investigates why people with HIV are more likely to develop chronic lung diseases like COPD. Researchers in Botswana will follow 900 adults aged 35 and older, with and without HIV, measuring lung function through activity tests and walking distance. The goal is to unco…

This study looks at the physical properties of lung mucus in people with obstructive pulmonary disease. Researchers will collect sputum samples before and after chest physiotherapy or exercise to see how these treatments change the mucus. The goal is to better understand the dise…

This study looks at how breathing in dust from the World Trade Center attacks may harm the heart and lungs of FDNY first responders. Researchers will measure certain substances in the blood and breathing tests to find early signs of disease. The goal is to better understand these…

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study observes oxygen levels in the airway during rigid bronchoscopy, a procedure to treat blocked airways. Researchers will measure how long it takes for oxygen to drop to a safe level when using a special ventilator mode. The goal is to reduce the risk of airway fires duri…

This study follows 600 adults who have received a stem cell transplant to learn more about a lung condition called bronchiolitis obliterans syndrome. Researchers will track how common this lung problem is and how it develops over time. No new treatments are being tested; the goal…