Neurotic disorder

This study tests whether taking propranolol, a beta blocker, before and after surgery can reduce complications like delirium, kidney problems, and pain in people with post-traumatic stress disorder (PTSD). Participants are veterans scheduled for certain surgeries and will take th…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This pilot study tested a 24-hour IV infusion of brexanolone in 10 adult women with PTSD from non-military trauma. The goal was to see if it could reduce PTSD symptoms and lead to remission by 12 weeks. The trial was terminated early, so results are limited.

This Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The appr…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study aimed to see if adding Problem Solving Therapy to standard suicide safety planning could reduce suicidal thoughts in older veterans (age 55+) with depression, anxiety, or PTSD. The trial planned to enroll 117 veterans but was terminated early. The approach focused on t…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study looked at whether using the Calm meditation app could help medical residents and fellows at Banner University Medical Center Phoenix feel less stressed, anxious, or burned out during the COVID-19 pandemic. Only 7 people signed up, and the study was stopped early, so we…

This pilot study tested a digital training task called GAMBIT in 50 adults with PTSD. The goal was to see if playing this brain-training game could improve brain circuit flexibility and reduce PTSD symptoms. The study was terminated early, so the findings are limited.

This study tested a new therapy that uses eye-tracking to help veterans with PTSD change how they look at threatening faces. The treatment, called Gaze-Contingent Music Reward Therapy, gives feedback based on where participants look, aiming to reduce stress. The trial included 12…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This small Phase 2 study aimed to test the safety and dosing of an intravenous drug called allopregnanolone (also known as brexanolone) in 11 people with chronic PTSD. The trial was terminated before completion, so results are limited. The main goal was to monitor sedation levels…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…