Myocarditis
MONDO:0004496Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.
Also known as: inflammation of myocardium, myocardial inflammation (finding), myocardium inflammation
54 clinical trials for this condition and its sub-types.
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Broader categories
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Could a targeted immune blocker tame a deadly heart side effect of cancer drugs?
Disease control CompletedThis phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Could a cannabidiol drug help heal inflamed hearts?
Disease control CompletedThis trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…
Phase: PHASE2 • Sponsor: Cardiol Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Wearable defibrillator jewel P-WCD tested in 322 High-Risk patients
Disease control CompletedThis study tested a wearable defibrillator called the Jewel P-WCD in 322 adults at high risk for sudden cardiac arrest. The device is designed to automatically deliver a shock to restore normal heart rhythm if a dangerous heart rhythm occurs. The main goals were to see how often …
Phase: NA • Sponsor: Element Science, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Can a heart drug save organs in sepsis? new trial aims to find out
Disease control CompletedThis completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in …
Phase: PHASE3 • Sponsor: University Hospital, Limoges • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New PET tracer could spot hidden heart inflammation
Diagnosis CompletedThis study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…
Phase: NA • Sponsor: Central Hospital, Nancy, France • Aim: Diagnosis
Last updated Jun 27, 2026 14:03 UTC
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ECMO studied in 761 severe COVID-19 patients: does it help?
Knowledge-focused CompletedThis study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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Study probes rare heart complication in kids with COVID-19
Knowledge-focused CompletedThis study looked back at 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and a possible COVID-19 infection. The goal was to describe their symptoms, lab results, and heart function, and to figure out whether the virus directly damages the he…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:04 UTC