Myocarditis
MONDO:0004496Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.
Also known as: inflammation of myocardium, myocardial inflammation (finding), myocardium inflammation
54 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Heart pump patients: does routine leg tube prevent limb loss?
Disease control Not yet recruitingThis study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…
Phase: NA • Sponsor: Samsung Medical Center • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Could a common arthritis drug save Children's hearts?
Disease control Not yet recruitingThis Phase 3 trial tests whether the anti-inflammatory drug anakinra can help children with acute myocarditis (heart inflammation) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo for 7 days, alongside standard care. Th…
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Herbal injection could shield hearts during sepsis
Disease control Not yet recruitingThis study tests whether a herbal medicine called Danhong injection can help protect the heart in people with sepsis, a life-threatening infection. Researchers will give 140 patients either the injection or a placebo for 7 days and check heart function and survival rates. The goa…
Phase: PHASE2 • Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New ultrasound could spot heart danger in cancer patients
Diagnosis Not yet recruitingThis early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…
Phase: EARLY_PHASE1 • Sponsor: University of Virginia • Aim: Diagnosis
Last updated Aug 14, 2026 00:00 UTC
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Radioactive tracer could spot hidden heart inflammation
Diagnosis Not yet recruitingThis early study tests a new radioactive tracer called 64Cu-GRIP B that targets a protein released by immune cells during heart inflammation. Researchers will scan 10 people with acute myocarditis to see if the tracer can clearly highlight inflamed areas of the heart. If it works…
Phase: PHASE1 • Sponsor: Javid Moslehi, MD • Aim: Diagnosis
Last updated Jun 27, 2026 11:03 UTC
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Immune clues in the blood may foretell heart trouble
Knowledge-focused Not yet recruitingThis study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Could a simple heart catheter test predict serious complications after myocarditis?
Knowledge-focused Not yet recruitingThis study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…
Sponsor: University Hospital, Grenoble • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Heart inflammation study seeks to predict deadly rhythms
Knowledge-focused Not yet recruitingThis study looks back at medical records of 1500 adults hospitalized for acute myocarditis (heart muscle inflammation). The goal is to find out how often dangerous heart rhythms occur and what factors predict them. No new treatments are tested—researchers will use existing data t…
Sponsor: AZ Sint-Jan AV • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Heart scans could spot hidden risks in lupus patients
Knowledge-focused Not yet recruitingThis study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Heart MRI registry aims to unlock myocarditis risk secrets
Knowledge-focused Not yet recruitingThis study will collect data from 5,000 adults with acute myocarditis (heart muscle inflammation) across France. Researchers will analyze heart MRI scans to see if certain patterns can predict who is at risk for serious complications like death, heart failure, or dangerous heart …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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New study aims to decode heart inflammation in kids
Knowledge-focused Not yet recruitingThis study will follow 100 children aged 1 to 18 with myocarditis (inflammation of the heart muscle) to see how different types of the disease progress. Researchers will track symptoms, treatments, and outcomes over one year. The goal is to better understand which children recove…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:54 UTC
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Could hidden heart inflammation cause those skipped beats?
Knowledge-focused Not yet recruitingThis study looks at 100 adults with frequent extra heartbeats (PVCs) to see if hidden heart inflammation (myocarditis) is the cause. Participants will get advanced heart scans and lab tests. The goal is to better understand the link and see if anti-inflammatory therapy helps thos…
Sponsor: Kansas City Heart Rhythm Research Foundation • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:36 UTC