Myocarditis
MONDO:0004496Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.
Also known as: inflammation of myocardium, myocardial inflammation (finding), myocardium inflammation
54 clinical trials for this condition and its sub-types.
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Broader categories
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Could a short course of steroids calm a dangerous heart rhythm?
Disease control ENROLLING_BY_INVITATIONThis trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…
Phase: PHASE4 • Sponsor: Roderick Tung • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New hope for long COVID heart sufferers: drug combo trial launches
Disease control OngoingThis study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and heart damage in people with Long COVID who have ongoing heart inflammation. About 279 adults with heart inflammation seen on MRI will receive either the drug combo or a …
Phase: PHASE3 • Sponsor: Valentina Puentmann • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Three extra minutes on an MRI could catch a deadly side effect of cancer treatment
Diagnosis OngoingThis study looks at whether adding just 3 minutes to a cardiac MRI can help doctors find heart inflammation (myocarditis) early in cancer patients on immunotherapy. Myocarditis is a rare but often deadly side effect of these drugs. The researchers will scan 200 patients who alrea…
Phase: NA • Sponsor: Centre Chirurgical Marie Lannelongue • Aim: Diagnosis
Last updated Jun 27, 2026 12:28 UTC
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Super MRI could spot hidden heart damage
Diagnosis OngoingThis study tests whether a new, more powerful 7 Tesla MRI can better detect scarring and swelling in the heart muscle of people with cardiomyopathy. Researchers will scan 13 adults aged 20-70 to see if the higher-resolution images improve diagnosis. The goal is to see if this adv…
Sponsor: University of Pennsylvania • Aim: Diagnosis
Last updated Jun 27, 2026 09:02 UTC
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Could your genes raise your risk of heart muscle inflammation?
Knowledge-focused OngoingThis study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…
Sponsor: French Cardiology Society • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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New study tracks heart inflammation in teens after pfizer vaccine
Knowledge-focused OngoingThis study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lastin…
Phase: PHASE4 • Sponsor: Pfizer • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Heart scans after COVID shot: new study aims to uncover hidden risks
Knowledge-focused OngoingThis study looks at 57 people who received a COVID-19 vaccine to understand why some develop heart injury or myocarditis. Researchers use advanced heart scans (PET/MRI) and blood tests to find early warning signs. The goal is to better identify those at risk and improve follow-up…
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Athletes' hearts under watch: new study tracks rhythm risks after myocarditis
Knowledge-focused OngoingThis study follows 50 athletes who had acute myocarditis (heart muscle inflammation) to see how often they develop dangerous heart rhythms. Participants wear a portable ECG monitor and do a treadmill stress test at 3 months and 1 year after their illness. The goal is to learn mor…
Phase: NA • Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Heart MRI study aims to spot who is at risk from myocarditis
Knowledge-focused ENROLLING_BY_INVITATIONThis study will use advanced cardiac MRI scans to look at different patterns of heart inflammation in 5,000 people with myocarditis or inflammatory cardiomyopathy. The goal is to see if certain MRI findings can better predict who will have serious heart problems later, like heart…
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Silent tumors may still harm the heart, new study warns
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…
Sponsor: Laikο General Hospital, Athens • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC