Myocardial ischemia

The RELEASE trial tests whether adults aged 65 and older with stable ischemic heart disease can safely stop their daily low-dose aspirin. Researchers will compare stopping aspirin against continuing it in 7,000 participants who have been free of heart events for at least two year…

This trial tests whether injecting a growth factor called FGF-1 directly into the heart can help people with severe coronary heart disease who have no other treatment options. The study compares low and high doses of FGF-1 against a placebo, using a special catheter to deliver th…

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This early-stage trial tests whether a patch loaded with lab-grown heart muscle cells can help repair damaged heart tissue. Sixteen people with severe heart failure who are already scheduled for bypass surgery will receive either the stem cell patch or a blank patch during their …

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This study is testing a new digital stethoscope that listens for subtle changes in heart sounds to detect coronary artery disease and valve problems earlier. Researchers will record heart sounds from 500 adults who are already scheduled for heart scans or echocardiograms. The goa…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study will compare two types of aerobic exercise—interval training and continuous training—in 48 people with stable coronary artery disease. Participants will exercise twice a week for 8 weeks as part of a cardiac rehab program. Researchers will measure heart efficiency, exe…

This phase 2 trial tests whether a traditional Chinese herbal paste called Chaigui Longmu Ejiao Paste can reduce weekly angina attacks in people with ischemic heart disease. Sixty adults aged 18-75 who have stable angina and are on standard heart medications will take the paste o…

This study tests whether a short virtual reality (VR) session before a first-time cardiac catheterization can lower patient anxiety and improve satisfaction. About 120 adults in Oman will be randomly assigned to either the VR experience or standard education. Researchers will mea…

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This observational study tests whether a new device, the SpectroCor Tissue Oxygenation Monitor, can accurately track oxygen levels in the heart muscle of children undergoing open-heart surgery. The device uses a sensor placed on the heart to measure oxygen availability during key…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This early-stage study will use advanced PET scans to look at how the brain and body work together in people with and without heart disease. Researchers want to see if blood flow and energy use in different organs change during physical or mental stress. The goal is to better und…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This study aims to improve how MRI scans measure blood flow in the heart muscle. Researchers will compare a new, fully quantitative method with the standard semi-quantitative approach in 35 people with possible heart disease. The goal is to develop a more accurate tool for diagno…

This study will check if measuring CO2 gap, lactate, and oxygen in the blood can help predict serious problems after heart bypass surgery. About 130 adults having planned bypass surgery will be followed for 7 days after their operation. The goal is to see if these simple tests ca…

This study tests new MRI and CT imaging methods to better identify scar tissue in the heart that causes a dangerous fast heartbeat called ventricular tachycardia (VT). About 15 adults with VT and heart disease will get these scans. The goal is to see if the scans can clearly show…