Can a heart injection grow new blood vessels?

NCT ID NCT00117936

NEW Not yet recruiting Disease control Sponsor: Venturis Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 19, 2026 · Last updated Aug 19, 2026

Summary

This trial tests whether injecting a growth factor called FGF-1 directly into the heart can help people with severe coronary heart disease who have no other treatment options. The study compares low and high doses of FGF-1 against a placebo, using a special catheter to deliver the injections. The goal is to see if the growth factor can stimulate new blood vessel growth, improve blood flow, and reduce chest pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Human recombinant fibroblast growth factor-1 (FGF-1), injected directly into the heart muscle
What this could lead to: If it works, this could offer a new treatment option for people with severe coronary heart disease who have no other options, potentially reducing chest pain and improving blood flow.
What could go wrong: This is a Phase 2 trial, so results are preliminary. The treatment involves invasive heart injections, and it may not improve symptoms or blood flow more than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERIOSCLEROSIS CORONARY DISEASE CORONARY HEART DISEASE MYOCARDIAL ISCHEMIA

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