Muscle tissue disorder
MONDO:0003939A disease involving the muscle tissue.
Also known as: disease of muscle organ, disease of muscle tissue, disease or disorder of muscle organ, disease or disorder of muscle tissue, disorder of muscle organ, disorder of muscle tissue, muscle organ disease, muscle organ disease or disorder
2419 clinical trials for this condition and its sub-types, 57 tagged with Muscle tissue disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Muscle tissue disorder
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Skeletal muscle disorder 10 trials · 1,363 incl. sub-types
13 sub-types
- Myopathy 15 trials · 987 incl. sub-types Sub-types →
- Hereditary skeletal muscle disorder 1 trial · 404 incl. sub-types Sub-types →
- Rotator cuff syndrome 272 trials
- Acquired skeletal muscle disease 0 trials · 166 incl. sub-types Sub-types →
- Diaphragm disorder 27 trials · 91 incl. sub-types Sub-types →
- Myotonic syndrome 11 trials · 61 incl. sub-types Sub-types →
- Anismus 12 trials
- Anterior compartment of tibia syndrome 1 trial
- Cyprus facial-neuromusculoskeletal syndrome 0 trials
- Tel Hashomer camptodactyly syndrome 0 trials
- Volkmann contracture 0 trials
- Muscular dystrophy-white matter spongiosis syndrome 0 trials
- Skeletal muscle neoplasm 0 trials Sub-types →
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Cardiomyopathy 155 trials · 819 incl. sub-types
12 sub-types
- Intrinsic cardiomyopathy 16 trials · 695 incl. sub-types Sub-types →
- Familial cardiomyopathy 2 trials · 217 incl. sub-types Sub-types →
- Tako-tsubo cardiomyopathy 16 trials
- Cardiomyopathy due to anthracyclines 16 trials
- Doxorubicin induced cardiomyopathy 7 trials
- Chagas cardiomyopathy 3 trials
- Extrinsic cardiomyopathy 3 trials Sub-types →
- Idiopathic cardiomyopathy 2 trials · 3 incl. sub-types Sub-types →
- Non-compaction cardiomyopathy 3 trials
- Keshan disease 0 trials
- Uhl anomaly 0 trials
- Autoimmune cardiomyopathy 0 trials Sub-types →
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Myomatous neoplasm 1 trial · 188 incl. sub-types
2 sub-types
- Smooth muscle tumor 2 trials · 187 incl. sub-types Sub-types →
- Benign muscle neoplasm 4 trials · 118 incl. sub-types Sub-types →
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Conduction system disorder 8 trials · 46 incl. sub-types
4 sub-types
- Sinoatrial node disorder 4 trials · 22 incl. sub-types Sub-types →
- Progressive familial heart block, type 1A 19 trials
- Atrioventricular node disorder 1 trial
- Atrial conduction disease 0 trials
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Myostatin-related muscle hypertrophy 10 trials
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Atrophic muscular disease 7 trials
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Distal arthrogryposis 0 trials · 3 incl. sub-types
23 sub-types
- Freeman-Sheldon syndrome 1 trial Sub-types →
- Congenital contractural arachnodactyly 1 trial
- Contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A 1 trial
- ACTC1-related distal arthrogryposis with congenital heart disease 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- Gordon syndrome 0 trials
- Sheldon-hall syndrome 0 trials Sub-types →
- Arthrogryposis, distal, IIa 11 0 trials
- Arthrogryposis, distal, type 12 0 trials
- Arthrogryposis, distal, type 1C 0 trials
- Arthrogryposis, distal, type 2B4 0 trials
- Arthrogryposis, distal, type 2E 0 trials
- Arthrogryposis, distal, with impaired proprioception and touch 0 trials
- Arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome 0 trials
- Arthrogryposis-ectodermal dysplasia-other anomalies syndrome 0 trials
- Arthrogryposis-like hand anomaly-sensorineural deafness syndrome 0 trials
- Arthrogryposis-severe scoliosis syndrome 0 trials
- Autism spectrum disorder - epilepsy - arthrogryposis syndrome 0 trials
- Digitotalar dysmorphism 0 trials Sub-types →
- Distal arthrogryposis Moore weaver type 0 trials
- Distal arthrogryposis type 10 0 trials
- Distal arthrogryposis type 5D 0 trials
- Trismus-pseudocamptodactyly syndrome 0 trials
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Kocher-debre-Semelaigne syndrome 0 trials
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Caveolinopathy 0 trials
1 sub-type
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Septal myocardial infarction 0 trials
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Striated muscle rhabdoid tumor 0 trials
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Tonsillar pillar cancer 0 trials
Most studied deeper sub-types
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Heart cell therapy shows promise for duchenne MD in major trial
Disease control OngoingThis Phase 3 trial tests a cell therapy called deramiocel (CAP-1002) in 106 boys and young men with Duchenne muscular dystrophy. Participants receive either the cell therapy or a placebo every 3 months for a year, then all can receive the therapy for another year. The goal is to …
Phase 3 • Sponsor: Capricor Inc. • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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New hope for muscle disease: experimental drug VX-670 enters human trials
Disease control OngoingThis early-stage trial tests the safety and tolerability of a new drug called VX-670 in 52 adults with myotonic dystrophy type 1 (DM1), a genetic condition that causes muscle weakness and other problems. Participants receive either VX-670 or a placebo, and researchers will monito…
Phase 1/2 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Vertex tests long-term safety of VX-670 for muscle disease
Disease control By invitation onlyThis study tests the long-term safety and effectiveness of an experimental drug called VX-670 in adults with myotonic dystrophy type 1 (DM1). Participants who completed a previous VX-670 study can join. The drug is given through a vein, and researchers will monitor side effects a…
Phase 2 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New drug aims to fix calcium levels in rare genetic disease
Disease control OngoingThis study tests a new drug called encaleret against usual treatments for people with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1), which causes low blood calcium and high urine calcium. About 67 participants will receive either encaleret or stand…
Phase 3 • Sponsor: Calcilytix Therapeutics, Inc., a BridgeBio company • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Zolgensma's long-term effects under the microscope in new 5-year study
Disease control OngoingThis study follows 175 people with spinal muscular atrophy who previously received the gene therapy Zolgensma in clinical trials. Researchers will monitor them for 5 years to track serious side effects and developmental milestones. The goal is to understand how safe and effective…
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Could this drug stop the body from turning muscle into bone?
Disease control OngoingThis study tests an experimental drug called andecaliximab in 92 children and adults with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition where soft tissues turn into bone. The goal is to see if the drug can safely reduce new bone growth and flare-ups. Parti…
Phase 2/3 • Sponsor: Ashibio Inc • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Lifting weights, lifting hope: exercise trial targets brain cancer decline
Symptom relief By invitation onlyThis study explores whether a supervised, circuit-based resistance training program can help glioblastoma patients maintain muscle mass and perform daily tasks more easily. Researchers will enroll 24 adults with glioblastoma who are currently on treatment. Participants will exerc…
Sponsor: Nova Scotia Health Authority • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New study monitors rare calcium disorder to better understand its long-term effects
Knowledge-focused OngoingThis study is for people with autosomal dominant hypocalcemia types 1 or 2, rare genetic conditions that cause low blood calcium. Researchers will collect past and future health data from 95 participants to learn how the disease changes over time. The goal is to better understand…
Sponsor: Calcilytix Therapeutics, Inc., a BridgeBio company • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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ICU muscle mystery: new study aims to uncover why patients stay weak
Knowledge-focused OngoingThis study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …
Sponsor: Vanderbilt University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Hidden muscle wasting in ICU: new study to reveal true toll
Knowledge-focused By invitation onlyThis study looks at how often muscle loss (sarcopenia) happens in adults who need a breathing machine in the ICU for more than 48 hours. Researchers will measure muscle health using simple tests and ultrasound. The goal is to understand how common this problem is and how it chang…
Sponsor: Hospital Mutua de Terrassa • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC