Lichen planus

This pilot study tests a topical cream called delgocitinib in 30 adults with two types of scarring hair loss: lichen planopilaris and central centrifugal cicatricial alopecia. Participants apply the cream twice daily for 48 weeks. The study focuses on safety and changes in immune…

This study compares three treatments for painful mouth sores caused by oral lichen planus, a long-term inflammatory condition. Sixty adults will receive either a steroid cream (standard care) or one of two light-based therapies (photobiomodulation or photodynamic therapy) to see …

This study tests an oral medication called brepocitinib for adults with lichen planopilaris, a condition that causes scalp inflammation, scarring, and hair loss. About 342 participants will receive either the drug or a placebo to see if it reduces symptoms and improves scalp appe…

This study tests a new drug called BG-A3004 for the first time in humans. It aims to check the drug's safety and how the body processes it in healthy volunteers and people with immune-related skin diseases. The study is split into two parts: single dose in healthy people and mult…

This study compares curcumin nanogels (a natural turmeric extract) to a standard steroid paste for treating atrophic-erosive oral lichen planus, a chronic inflammatory mouth condition. Thirty adults will apply either treatment three times daily for four weeks. Researchers will me…

This study tests a honey-based paste against a standard steroid ointment for treating painful mouth sores caused by oral lichen planus. Fifty-six adults with erosive or atrophic lichen planus will use the paste daily for four months. Researchers will track symptom improvement, pa…

This pilot study tests nemolizumab, a drug already approved for other skin conditions, in 10 adults with lichen planopilaris (LPP), a disease that causes permanent hair loss and scalp itching or burning. The goal is to see if the drug can reduce disease activity and improve sympt…

This study tests whether adding the drug tofacitinib to standard steroid ointment can better control oral lichen planus, a chronic inflammatory mouth condition. About 60 adults with moderate to severe disease will receive either tofacitinib pills or placebo alongside their usual …

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study compares a pineapple-derived enzyme (bromelain) to standard steroid treatment for oral lichen planus, a chronic inflammatory condition causing painful mouth sores. Researchers will enroll 42 adults with symptoms to see if bromelain reduces sores and pain as effectively…

This study is testing an oral spray called OROSEDAL to see if it helps relieve pain from sore throats, canker sores, and other minor mouth lesions. About 124 children and adults will use the spray as prescribed and report their pain levels over 6 days. The spray works by forming …

This study is testing a new gel dressing for women with vaginal atrophy, lichen sclerosus, or similar vulvar skin conditions. About 2000 adult women will use the gel and report their symptoms and quality of life over 12 months. The goal is to see if the gel safely reduces discomf…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This small phase 2 trial is testing whether tranexamic acid, a drug used to reduce bleeding, can lighten dark patches on the skin caused by lichen planus pigmentosus and erythema dyschromicum perstans. Five adults will take the drug twice daily for six months. Researchers will me…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study follows 300 people with oral lichen planus (a chronic mouth condition) for at least 6 months to see how often it turns into oral cancer. Researchers will also look for patterns and risk factors that might predict this change. No new treatments are tested—the goal is si…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…