Invasive ductal breast carcinoma

This study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects com…

This study is for women whose breast cancer has come back after initial breast-conserving surgery and whole breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 sessions…

This pilot study is testing whether partial breast irradiation alone — without first removing or sampling lymph nodes from the armpit — is safe for women age 40 and older with early-stage invasive breast cancer. All participants have had a lumpectomy but no sentinel node biopsy o…

This study tests whether adding hormone therapy to standard chemotherapy and HER2-targeted therapy improves tumor response before surgery in people with HER2-positive breast cancer. About 30 adults with stage II to III disease will participate. The goal is to see if this combinat…

This study compares a freezing technique called cryoablation to standard lumpectomy surgery in people with low-risk, early-stage breast cancer. The goal is to see if freezing the tumor offers similar disease control with fewer complications and better quality of life. About 120 p…

This study is testing a single, focused dose of radiation delivered by the GammaPod machine before lumpectomy surgery for early-stage breast cancer. The goal is to find a safe and effective dose that minimizes side effects and improves cosmetic outcomes. About 50 women with invas…

This study tests a device called SIRA-1000 that uses heat to destroy any cancer cells left behind after a lumpectomy for breast cancer. About 10 women aged 50 and older with a specific type of breast cancer will take part. The goal is to see if the device is safe and works well a…

This phase 2 trial is testing whether giving a short course of radiation (SBRT) and two injections of the immunotherapy drug pembrolizumab (Keytruda) before standard chemotherapy can improve outcomes for people with stage 2 or 3 breast cancer. The study aims to see if this combin…

This study is testing a new way to treat early-stage breast cancer without traditional surgery. It uses a device that sends electric pulses to destroy the tumor. The goal is to see if this approach is safe and can kill all cancer cells. About 24 women with small, early-stage brea…

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. Fifteen women with small, early-stage breast cancers will receive HIFU before their planned surgery. The main goal is to see if the ultrasound completely kills the tumor c…

This study tests proton radiation therapy for women with early-stage breast cancer. The goal is to see if targeting only the tumor area can keep cancer from coming back while causing fewer side effects. About 132 women aged 50 and older will take part. Researchers will track recu…

This study is testing a new blood test called Oncoliq to see if it can find breast cancer early. Researchers will collect blood from 300 women, some with breast cancer and some without, to check for tiny molecules called miRNAs that tumors release. The goal is to create a simple,…

This study tests a special MRI technique called TMEM-MRI that looks at the tumor environment to see how likely breast cancer is to spread. About 95 women with operable breast cancer will get this MRI before their standard biopsy or surgery. The goal is to see if this imaging meth…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…